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Related Experiment Video

Updated: Jun 7, 2025

Multimodal Volumetric Retinal Imaging by Oblique Scanning Laser Ophthalmoscopy oSLO and Optical Coherence Tomography OCT

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High-resolution optical coherence tomography using a multi-level diffractive lens.

Ameer Hamza, Tina M Hayward, Apratim Majumder

|November 14, 2024

Summary

This summary is machine-generated.

A new optical coherence tomography (OCT) system uses a multi-level diffractive lens (MDL) to achieve enhanced lateral resolution for deep tissue imaging. This innovation promises improved performance in high-resolution OCT applications.

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Published on: October 2, 2021

Area of Science:

Biomedical Optics
Optical Engineering
Medical Imaging Technology

Background:

Optical Coherence Tomography (OCT) is a key non-invasive imaging modality.
Enhancing lateral resolution and depth of focus in OCT remains a significant challenge.
Diffractive optical elements offer potential for miniaturization and improved optical performance.

Purpose of the Study:

To develop and evaluate a high-resolution OCT system incorporating a multi-level diffractive lens (MDL).
To investigate the impact of MDL on lateral resolution and depth of focus in OCT imaging.
To demonstrate the system's capability for deep tissue imaging applications.

Main Methods:

Implementation of a polygon-based swept laser source (1,000 nm center wavelength).
Integration of a multi-level diffractive lens (MDL) to improve lateral resolution.
Utilizing a semiconductor optical amplifier in a bidirectional configuration for enhanced imaging depth.
Imaging performance validated using phantom and onion samples.

Main Results:

Achieved an axial resolution of 5.6 µm and an imaging depth of 1.4 mm.
The MDL significantly improved lateral resolution to an average of 8.5 µm.
Extended depth of focus of 550 µm was achieved with the MDL.
Successful high-resolution imaging of phantom and onion samples was demonstrated.

Conclusions:

Compact MDLs can substantially enhance the lateral resolution and imaging performance of OCT systems.
The developed OCT system shows potential for advanced high-resolution deep tissue imaging.
This approach offers a promising direction for next-generation OCT instrumentation.