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Updated: Jun 7, 2025

Antimicrobial Synergy Testing by the Inkjet Printer-assisted Automated Checkerboard Array and the Manual Time-kill Method
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Antimicrobial Synergy Testing by the Inkjet Printer-assisted Automated Checkerboard Array and the Manual Time-kill Method

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Adjuvant strategies to tackle mcr-mediated polymyxin resistance

Madison R Nuske1,2, Junlang Zhong1,2, Renjie Huang3

  • 1School of Chemistry, The University of Melbourne Parkville Victoria 3010 Australia ivanhoe.leung@unimelb.edu.au.

RSC Medicinal Chemistry
|November 14, 2024
PubMed

Insights

Mobile colistin resistance (mcr) genes on plasmids threaten antibiotic use. This review explores polymyxin adjuvants and MCR inhibitors to combat resistance and restore antibiotic effectiveness.

Area of Science:

  • Microbiology
  • Molecular Biology
  • Pharmacology

Background:

  • Mobile colistin resistance (mcr) genes are a growing global health threat, facilitating antibiotic resistance spread via plasmids.
  • MCR enzymes modify lipopolysaccharides (LPS), preventing polymyxin binding and conferring resistance to these critical last-resort antibiotics.

Purpose of the Study:

  • To review recent advancements in developing polymyxin adjuvants to overcome mcr-mediated resistance.
  • To focus on strategies including MCR inhibitors and alternative approaches to restore polymyxin efficacy.

Main Methods:

  • Literature review of recent research on mcr genes, polymyxin resistance mechanisms, and adjuvant development.
  • Analysis of studies focusing on MCR inhibitors and other resistance modulation strategies.

Main Results:

  • Polymyxin adjuvants show promise in restoring sensitivity to polymyxins in resistant bacteria.
  • MCR inhibitors and alternative approaches are being actively investigated to combat resistance.

Conclusions:

  • Developing polymyxin adjuvants is a crucial strategy to extend the utility of last-resort antibiotics.
  • Continued research into MCR inhibitors and novel resistance modulation techniques is essential for addressing the antibiotic resistance crisis.

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