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The causal relationship between trace element status and upper gastrointestinal ulcers: a Mendelian randomization
1Department of Gastroenterology, Qilu Hospital (Qingdao) of Shandong University, Qingdao, China.
Frontiers in Nutrition
|November 14, 2024
Summary
This study found that higher zinc levels increase the risk of gastric ulcers. Magnesium and folate may protect against gastroduodenal ulcers, offering insights for dietary strategies.
Area of Science:
- Nutritional science
- Gastroenterology
- Genetics
Background:
- Investigating the complex interplay between essential trace elements and upper gastrointestinal disorders.
- Focusing on potential bidirectional causal links between nutrients like zinc, magnesium, folate, and conditions such as gastric and duodenal ulcers.
Purpose of the Study:
- To elucidate the causal relationships between key trace elements and the incidence of upper gastrointestinal ulcers.
- To leverage genetic data for robust causal inference in nutritional and gastrointestinal research.
Main Methods:
- Employed a two-sample Mendelian randomization (MR) analysis using large-scale genome-wide association study (GWAS) summary data.
- Utilized multiple MR methods (IVW, MR-Egger, weighted median) and meta-analysis for result synthesis.
- Conducted comprehensive sensitivity analyses to ensure the reliability and validity of findings.
Main Results:
- Identified a significant positive causal effect of elevated zinc levels on the risk of developing gastric ulcers.
- Observed potential protective effects of magnesium and folate against gastroduodenal ulcers.
- Meta-analysis confirmed the causal link between zinc and gastric ulcers, underscoring its impact.
Conclusions:
- Confirmed a causal relationship between zinc and gastric ulcers, highlighting trace elements' role in ulcer development.
- Results support evidence-based dietary recommendations for managing and preventing upper gastrointestinal ulcers.
- Provides novel perspectives for clinical and public health interventions targeting gastric and duodenal ulcers.
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