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Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

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Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
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Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
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In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
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Related Experiment Video

Updated: Jun 7, 2025

Retinal Pigment Epithelium Transplantation in a Non-human Primate Model for Degenerative Retinal Diseases
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Unified Approach to Treating Exogenous Endophthalmitis With Immediate Vitrectomy.

Graeme K Loh1, Amit V Mishra1, Mark Seamone1

  • 1Department of Ophthalmology and Visual Sciences, University of Alberta, Edmonton, AB, Canada.

Journal of Vitreoretinal Diseases
|November 14, 2024
PubMed
Summary
This summary is machine-generated.

Immediate small-gauge pars plana vitrectomy (PPV) significantly improves vision for patients with exogenous endophthalmitis. While complications like retinal detachment can occur, this surgery offers a positive visual outcome for most patients.

Keywords:
acute endophthalmitisearly vitrectomyexogenous endophthalmitisimmediate vitrectomypars plana vitrectomysmall gauge

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Area of Science:

  • Ophthalmology
  • Surgical Innovation

Background:

  • Exogenous endophthalmitis is a severe intraocular infection.
  • Prompt treatment is crucial for preserving vision.

Purpose of the Study:

  • To evaluate the efficacy and safety of immediate small-gauge pars plana vitrectomy (PPV) for exogenous endophthalmitis.
  • To analyze visual outcomes and complication rates following PPV.

Main Methods:

  • Retrospective case series analysis of 107 patients.
  • Inclusion of patients undergoing immediate (within 24 hours) 23-gauge or 25-gauge PPV.
  • Assessment of best-corrected visual acuity (BCVA) changes and post-operative complications.

Main Results:

  • The most common causes of endophthalmitis were intravitreal injections (62.6%) and prior PPV (18.7%).
  • Significant improvement in mean logMAR BCVA from 2.26 to 1.21 (P < .0001).
  • Key complications included retinal detachment (17.8%) and secondary glaucoma (9.3%).

Conclusions:

  • Immediate small-gauge PPV is effective in improving visual acuity in exogenous endophthalmitis.
  • Visual improvement is observed irrespective of initial visual acuity.
  • Informed consent regarding potential surgical risks is essential for patients.