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Related Concept Videos

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
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Updated: Jun 7, 2025

Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus
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Anaplastic Large B-Cell Lymphoma: Cutaneous Presentations.

Ian Depew1, William T Snider1, Shane Cook1

  • 1Department of Dermatology, Marshall University Joan C. Edwards School of Medicine, Huntington, USA.

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|November 14, 2024
PubMed
Summary

Anaplastic large cell lymphoma (ALCL) can mimic infections, delaying diagnosis. Early skin biopsy and molecular testing are crucial for timely treatment and improved outcomes in pediatric ALCL cases.

Keywords:
alk-negative alclanaplastic large cell lymphomabrentuximab therapycd30-positive lymphomachemotherapy treatmentcutaneous involvementlymph node biopsypediatric lymphomaprimary cutaneous alclt-cell neoplasm

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Area of Science:

  • Pediatric Oncology
  • Dermatology
  • Hematology

Background:

  • Anaplastic large cell lymphoma (ALCL) is a rare CD30-expressing T-cell lymphoma.
  • Diagnosis can be challenging due to non-specific symptoms mimicking benign conditions.

Observation:

  • A 10-year-old female presented with persistent skin lesions initially misdiagnosed as infection.
  • Biopsy confirmed ALK-negative ALCL with cutaneous, nodal, and pulmonary involvement (Murphy stage II).

Findings:

  • The case highlights diagnostic difficulties in pediatric ALCL.
  • Standard treatments failed, necessitating further investigation.

Implications:

  • Emphasizes the critical role of early skin biopsy and molecular testing for accurate ALCL diagnosis.
  • Highlights the importance of routine examinations, including lymph node and skin assessments, for prompt recognition and effective treatment planning in pediatric oncology.
  • Timely diagnosis of ALCL is essential for initiating appropriate chemotherapy and improving patient prognosis.