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Emerging roles of long non-coding RNA FOXP4-AS1 in human cancers: From molecular biology to clinical application

Jingjie Yang1,2

  • 1Hubei Key Laboratory of Tumor Microenvironment and Immunotherapy, China Three Gorges University, Yichang, 443002, China.

Heliyon
|November 14, 2024
PubMed

Insights

Forkhead box P4 antisense RNA 1 (FOXP4-AS1), a long non-coding RNA, plays a complex role in cancer, acting as both a tumor suppressor and oncogene. Its dysregulation impacts cancer progression and patient prognosis, highlighting its potential as a therapeutic target.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Forkhead box P4 antisense RNA 1 (FOXP4-AS1) is a long non-coding RNA (lncRNA) located at chromosome 6p21.1.
  • FOXP4-AS1 is dysregulated in various cancers, exhibiting dual roles as a tumor suppressor or oncogene.
  • Its expression levels correlate with clinical cancer features and patient prognosis.

Purpose of the Study:

  • To review the latest advancements in FOXP4-AS1 oncology research.
  • To outline the molecular regulatory networks of FOXP4-AS1 in cancer.
  • To discuss the potential of FOXP4-AS1 as a therapeutic target and biomarker.

Main Methods:

  • Literature review of FOXP4-AS1 in cancer research.
  • Analysis of molecular mechanisms including miRNA sponging and pathway activation.
  • Examination of FOXP4-AS1's role in regulating cancer phenotypes.

Main Results:

  • FOXP4-AS1 is regulated by transcription factors ATF3, YY1, PAX5, and SP4.
  • It influences cancer through miRNA sponging, regulating host gene FOXP4, and activating signaling pathways (PI3K/AKT, Wnt/β-catenin, ERK/MAPK).
  • FOXP4-AS1 affects tumor proliferation, invasion, epithelial-mesenchymal transition (EMT), and angiogenesis.

Conclusions:

  • FOXP4-AS1 is a key player in cancer development and progression.
  • Understanding its complex molecular mechanisms is crucial for therapeutic development.
  • FOXP4-AS1 shows promise as a diagnostic and prognostic biomarker in oncology.
Keywords:
Biological functionCancerFOXP4-AS1LncRNAMolecular mechanism

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