Predicting susceptibility to COVID-19 infection in patients on maintenance hemodialysis by cross-coupling soluble ACE2 concentration with lymphocyte count: an algorithmic approach
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View abstract on PubMed
Summary
This summary is machine-generated.Patients on maintenance hemodialysis (MHD) are vulnerable to COVID-19. Higher soluble angiotensin converting enzyme 2 (sACE2) and lower transmembrane protease serine S1 member 2 (TMPRSS2) levels are linked to increased infection risk in MHD patients.
Area Of Science
- Nephrology
- Infectious Diseases
- Virology
Background
- Patients on maintenance hemodialysis (MHD) faced increased vulnerability and mortality during the COVID-19 pandemic.
- Angiotensin converting enzyme 2 (ACE2) and transmembrane protease serine S1 member 2 (TMPRSS2) are key for viral entry into host cells.
Purpose Of The Study
- To investigate the association between plasma levels of ACE2, ACE, and TMPRSS2 and COVID-19 susceptibility in MHD patients.
- To identify predictive markers for COVID-19 infection risk in this vulnerable population.
Main Methods
- Plasma levels of soluble ACE2 (sACE2), ACE (sACE), and TMPRSS2 (sTMPRSS2) were measured using ELISA in 174 MHD patients.
- Logistic regression, ROC curve, and multiple dimensionality reduction (MDR) were employed to analyze susceptibility factors.
Main Results
- Of 174 patients, 95 (54.6%) tested positive for COVID-19.
- Infected patients exhibited significantly higher sACE2 and lower sTMPRSS2 levels compared to uninfected individuals.
- Increased susceptibility was associated with higher sACE2, lower sTMPRSS2, longer dialysis vintage, longer session time, smoking, hepatitis comorbidity, and lower lymphocyte counts.
Conclusions
- Higher sACE2 and lower lymphocyte counts were identified as key indicators of increased COVID-19 infection risk in MHD patients.
- This algorithmic approach can help identify susceptible MHD patients for proactive management against future viral outbreaks.
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