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Updated: Jun 7, 2025

High-Throughput Assays of Critical Thermal Limits in Insects
Published on: June 15, 2020
Validation of livability environmental limits to heat and humidity
Xiaojiang Xu1, Timothy P Rioux1, John W Castellani1
1Thermal and Mountain Medicine Division, U.S. Army Research Institute of Environmental Medicine, Natick, Massachusetts, United States.
Abstract:
Rising global temperatures, driven by climate change, pose a threat to human health and regional livability. Empirical data and biophysical model-derived estimates suggest that the critical environmental limits (CELs) for livability are dependent on ambient temperature and humidity. We use a well-validated, physiology-based, six-cylinder thermoregulatory model (SCTM) to independently derive CELs during sustained minimal, light, and moderate activity across a broad range of ambient temperatures and humidity levels and compare with published data. The activity and environments were considered livable if predicted core temperatures did not reach 38 ± 0.25°C within 6 h. The outcomes for minimal activity revealed CELs ranging from 34°C/95% relative humidity (RH) to 50°C/5% RH. Corresponding dry heat losses ranged from 14 to -72 W·m-2 (negative = heat gain) and evaporative heat losses ranged from 39 to 104 W·m-2. The wet-bulb temperature (Twb) at the CELs ranged from 33.3°C to 20.9°C. Activity shifted CELs toward lower temperatures and humidities. Importantly, our predicted CELs largely agree with observed livability CELs from physiology and those from a biophysical model. The physiology-grounded SCTM has utility for assessing the impact of climate change on regional livability.NEW & NOTEWORTHY This study is the first to use a physiology-grounded thermoregulatory model to predict critical environmental limits (CELs) above which human thermoregulatory capacity is exceeded. The model outcomes closely approximate empirically derived CELs, showing it is a strong model for estimating and preparing for the impact of climate warming on local, regional, and world human population livability and migration.
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