Related Experiment Video
Updated: Jun 7, 2025
09:01
Analysis of Human T Cell Activity in an Allogeneic Co-Culture Setting of Pre-Treated Tumor Cells
Published on: March 7, 2025
296
The UBA1-STUB1 Axis Mediates Cancer Immune Escape and Resistance to Checkpoint Blockade
Yi Bao1,2, Gabriel Cruz1,2, Yuping Zhang1,2
1Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, Michigan.
Cancer Discovery
|November 14, 2024
Abstract
Significance:
Our study reveals UBA1 as a predictive biomarker for clinical outcomes in ICB cohorts, mediating cancer immune evasion and ICB resistance. We further highlight JAK1 stabilization as a key mechanism of UBA1 inhibition and nominate the UBA1-STUB1 axis as an immuno-oncology therapeutic target to improve the efficacy of ICB.
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