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Cocrystallization Enables Ensitrelvir to Overcome Anomalous Low Solubility Caused by Strong Intermolecular

Tetsuya Miyano1, Shigeru Ando1, Daiki Nagamatsu1

  • 1Laboratory for Medicinal Chemistry Research, Shionogi & Co., Ltd., Osaka 561-0825, Japan.

Molecular Pharmaceutics
|November 14, 2024
PubMed
Summary

Ensitrelvir crystalline forms were studied for treating coronavirus disease 2019. Cocrystallization with fumaric acid significantly improved ensitrelvir

Keywords:
COVID-19cocrystalcrystal engineeringintermolecular interactionsingle-crystal structure analysissolubility

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