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Cushing's syndrome and COVID-19
Amina Attia1,2, Jérôme Bertherat3,4,5
1Université Paris-Cité, Paris, 75006, France. amina.attia@aphp.fr.
Patients with Cushing syndrome (CS) face increased COVID-19 risk and severity due to immune system impacts and comorbidities. Special attention and caution are recommended for managing CS during the pandemic.
Area of Science:
- Endocrinology
- Infectious Diseases
- Immunology
Background:
- Cushing syndrome (CS) involves chronic hypercortisolism, impacting the immune system.
- Metabolic complications of CS, such as diabetes and hypertension, are known risk factors for severe COVID-19.
Purpose of the Study:
- To review current data on COVID-19 course in patients with Cushing syndrome.
- To discuss management strategies for Cushing syndrome during the COVID-19 pandemic.
Main Methods:
- A literature review was conducted using PubMed.
- Search terms included "COVID19" combined with "Cushing syndrome", "Hypercortisolism", and "Glucocorticoid".
Main Results:
- Hypercortisolism increases infectious risk and worsens COVID-19 prognosis by impairing immune cell function.
- CS metabolic complications (diabetes, hypertension, obesity) are COVID-19 risk factors.
- Patients on steroidogenesis inhibitors may develop adrenal insufficiency during COVID-19; pandemic impacted CS care, necessitating telemedicine and delayed procedures.
Conclusions:
- Evidence indicates increased prevalence and severity of COVID-19 in Cushing syndrome patients.
- Specific attention and caution are warranted for managing COVID-19 in individuals with CS.
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