Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Antimicrobial Proteins

Antimicrobial Proteins

Antimicrobial proteins are important components of the immune system. They aid the body in combating pathogens by either killing them directly or hindering their replication processes. Four main types of antimicrobial substances are interferons, the complement system, iron-binding proteins, and antimicrobial proteins.
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Synergistic Potential of Plant Alkaloids and Intragenic Antimicrobial Peptides in Treating Multidrug-Resistant Infectious Diseases.

Antibiotics (Basel, Switzerland)·2026

Same author

Cyclotides from Plants Driving the Next Generation of Antibacterial Agents.

Antibiotics (Basel, Switzerland)·2026

Same author

Deep learning reveals antimicrobial peptides within prions.

Nature microbiology·2026

Same author

Unraveling the mechanism of action of the PepGAT peptide against Candida albicans through proteomics approaches.

Scientific reports·2026

Same author

A generative artificial intelligence approach for peptide antibiotic optimization.

Nature machine intelligence·2026

Same author

Computer-Aided Design of <i>Plasmodium chabaudi</i>-Derived Peptides with Dual Antibiofilm and Anti-inflammatory Activities.

ACS medicinal chemistry letters·2026

Search research articles

Related Experiment Video

Updated: Jun 7, 2025

A Tripeptide-Stabilized Nanoemulsion of Oleic Acid

A Tripeptide-Stabilized Nanoemulsion of Oleic Acid

Published on: February 27, 2019

Computational Approaches for Antimicrobial Peptide Delivery.

Thuanny Borba Rios^1,2, Samilla Beatriz Rezende¹, Mariana Rocha Maximiano^1,2

¹S-Inova Biotech, Pós-Graduação em Biotecnologia, Universidade Católica Dom Bosco, Campo Grande, Mato Grosso do Sul 70990-160, Brazil.

Bioconjugate Chemistry

|November 14, 2024

Summary

This summary is machine-generated.

Peptide therapeutics show promise for infections but face delivery challenges. Computational strategies can accelerate the development of nanoparticle drug delivery systems for improved peptide effectiveness.

More Related Videos

Development of a Backbone Cyclic Peptide Library as Potential Antiparasitic Therapeutics Using Microwave Irradiation

Development of a Backbone Cyclic Peptide Library as Potential Antiparasitic Therapeutics Using Microwave Irradiation

Published on: January 26, 2016

Construction of Cyclic Cell-Penetrating Peptides for Enhanced Penetration of Biological Barriers

Construction of Cyclic Cell-Penetrating Peptides for Enhanced Penetration of Biological Barriers

Published on: September 19, 2022

Related Experiment Videos

Last Updated: Jun 7, 2025

A Tripeptide-Stabilized Nanoemulsion of Oleic Acid

A Tripeptide-Stabilized Nanoemulsion of Oleic Acid

Published on: February 27, 2019

Development of a Backbone Cyclic Peptide Library as Potential Antiparasitic Therapeutics Using Microwave Irradiation

Development of a Backbone Cyclic Peptide Library as Potential Antiparasitic Therapeutics Using Microwave Irradiation

Published on: January 26, 2016

Construction of Cyclic Cell-Penetrating Peptides for Enhanced Penetration of Biological Barriers

Construction of Cyclic Cell-Penetrating Peptides for Enhanced Penetration of Biological Barriers

Published on: September 19, 2022

Area of Science:

Drug delivery systems
Computational chemistry
Antimicrobial peptides

Background:

Peptides are potential antimicrobial agents against various pathogens.
Therapeutic use of peptides is hindered by instability, degradation, and toxicity.
Current nanoparticle formulation relies heavily on trial-and-error methods.

Purpose of the Study:

To explore computational strategies for optimizing peptide-based drug delivery.
To accelerate the development of effective nanoparticle carriers for therapeutic peptides.
To improve the pharmacokinetic and pharmacodynamic profiles of peptide drugs.

Main Methods:

Review of computational approaches for designing peptide drug delivery systems.
Analysis of nanoparticle-peptide interactions using in silico methods.
Discussion of strategies to enhance peptide stability and targeted delivery.

Main Results:

Computational methods offer a faster, more efficient alternative to traditional trial-and-error in nanoparticle design.
In silico modeling can predict and optimize peptide loading, release kinetics, and stability within nanoparticles.
These approaches have the potential to significantly reduce development time and cost.

Conclusions:

Computational strategies are crucial for advancing peptide-based therapeutics.
Optimized nanoparticle delivery systems can overcome key limitations of peptide drugs.
This approach promises to enhance the clinical utility of peptides for treating infectious diseases.