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Creation of Abdominal Adhesions in Mice
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Lycopene Inhibits Postoperative Abdominal Adhesion Formation in a Mouse Model
HaoChongyang Tong1, ChangChun Ye1, Lei Fu2
1Department of General Surgery, The First Affliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
The Journal of Surgical Research
|November 14, 2024
Summary
Lycopene effectively reduces postoperative abdominal adhesions in mice by decreasing inflammation and oxidative stress. This natural compound may offer a new therapeutic strategy for preventing surgical complications.
Area of Science:
- Surgical research
- Gastroenterology
- Pharmacology
Background:
- Postoperative abdominal adhesions are a significant surgical concern.
- Effective interventions to prevent adhesions are crucial for patient outcomes.
Purpose of the Study:
- To investigate the efficacy of lycopene in preventing postoperative abdominal adhesions in a mouse model.
- To explore the underlying mechanisms of lycopene's anti-adhesion effects.
Main Methods:
- A mouse model of abdominal adhesions was established.
- Mice were treated with varying doses of lycopene, sodium hyaluronate, or saline.
- Adhesion scores, inflammation markers (interleukin-6, transforming growth factor-β1), oxidative stress indicators, and specific protein expressions were analyzed.
Main Results:
- Lycopene at 20 μg/kg significantly reduced adhesion scores and inflammation.
- Lycopene treatment lowered levels of oxidative stress markers and collagen deposition.
- Lycopene promoted the expression of nuclear factor erythroid 2-related factor 2 and silent information regulator 1.
- In vitro studies showed lycopene protected mesothelial cells from oxidative stress.
Conclusions:
- Lycopene demonstrates significant potential in attenuating abdominal adhesions.
- The mechanism involves reducing inflammation and oxidative stress.
- Upregulation of Nrf2 and SIRT1 pathways may contribute to lycopene's protective effects.
