Recent progress of natural materials-based hydrogel for postoperative chemotherapy

Area of Science:

• Biomaterials Science
• Oncology
• Drug Delivery Systems

Background:

• Systemic chemotherapy often leads to significant side effects and limited drug action duration.
• Hydrogels are increasingly utilized for localized postoperative chemotherapy, offering improved therapeutic outcomes.
• Natural materials-based hydrogels are being explored for their biocompatibility and biodegradability in drug delivery applications.

Purpose of the Study:

• To review the application of natural materials-based hydrogels for in situ postoperative chemotherapy following tumor resection.
• To explore hydrogels as a viable option for localized chemotherapy delivery.
• To summarize different types of hydrogels and their clinical applications in this context.

Main Methods:

• Comprehensive literature review of natural materials-based hydrogels for postoperative chemotherapy.
• Investigation of various material-based and response-based hydrogel systems.
• Analysis of clinical applications including implantable, injectable, and sprayed hydrogel formulations.

Main Results:

• Natural materials-based hydrogels demonstrate potential for sustained drug release at the tumor site.
• Different hydrogel types (material-based, response-based) show varied efficacy and applicability.
• Implantable, injectable, and sprayed hydrogel delivery systems offer diverse clinical administration routes.

Conclusions:

• Hydrogel-based local drug delivery systems represent a promising strategy for postoperative chemotherapy.
• These systems offer advantages such as reduced systemic toxicity and prolonged therapeutic effect.
• Further research into natural materials-based hydrogels can optimize their clinical application prospects.