Related Experiment Video

Updated: Jun 7, 2025

Author Spotlight: Network Pharmacology and Molecular Docking to Decipher the Action of Jiawei Shengjiang San Against Diabetic Kidney Disease
08:15

Author Spotlight: Network Pharmacology and Molecular Docking to Decipher the Action of Jiawei Shengjiang San Against Diabetic Kidney Disease

Published on: May 10, 2024

500

Crosstalk between non-coding RNA and apoptotic signaling in diabetic nephropathy

Kejia Zhang1, Di Wu1, Chunjie Huang1

  • 1Institute of Reproductive Medicine, School of Medicine, Nantong University, Nantong 226001, China.

Biochemical Pharmacology
|November 14, 2024
PubMed

Insights

Diabetic nephropathy (DN) involves cell death regulated by non-coding RNAs (ncRNAs). This study explores how microRNAs, long non-coding RNAs, and circular RNAs interact in DN apoptosis, offering new therapeutic targets.

Area of Science:

  • Molecular Biology
  • Genetics
  • Nephrology

Background:

  • Diabetic nephropathy (DN) is a major cause of end-stage renal disease and cardiovascular complications in diabetes mellitus.
  • Hyperglycemia in diabetes induces apoptosis (programmed cell death) in renal cells, contributing to DN pathogenesis.
  • Regulatory non-coding RNAs (ncRNAs), including microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), are crucial for cellular homeostasis and implicated in DN.

Purpose of the Study:

  • To analyze the complex interactions between miRNAs, lncRNAs, and circular RNAs in the context of apoptosis during DN pathogenesis.
  • To explore potential therapeutic strategies targeting ncRNA-mediated apoptosis modulation for DN treatment.

Main Methods:

  • Review and analysis of existing literature on ncRNAs, apoptosis, and diabetic nephropathy.
  • Investigation of the interplay between different classes of ncRNAs (miRNAs, lncRNAs, circular RNAs) and their role in renal cell apoptosis.
  • Exploration of ncRNA-mediated therapeutic approaches, including stem cell-derived exosomes and herbal medicines.

Main Results:

  • Dysregulation of miRNAs, lncRNAs, and circular RNAs is closely linked to apoptotic processes in diabetic nephropathy.
  • These ncRNAs play a significant role in the intricate molecular pathways contributing to DN.
  • ncRNA-mediated modulation of apoptosis presents promising therapeutic avenues for DN.

Conclusions:

  • Understanding the interplay of ncRNAs and apoptosis is essential for developing effective treatments for diabetic nephropathy.
  • Stem cell-derived exosomes and herbal medicines show potential for ncRNA-based therapeutic interventions in DN.
  • Targeting ncRNA-mediated apoptosis offers a novel strategy to retard the progression of diabetic nephropathy.
Keywords:
ApoptosisDiabetic nephropathyExosomeHerbal medicinesHyperglycemiNon-coding-RNA

More Related Videos

Mechanism of Kemeng Fang's Inhibition of Podocyte Apoptosis in Rats with Membranous Nephropathy through the PI3K/AKT Signaling Pathway07:15

Mechanism of Kemeng Fang's Inhibition of Podocyte Apoptosis in Rats with Membranous Nephropathy through the PI3K/AKT Signaling Pathway

Published on: August 23, 2024

346
Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice10:37

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice

Published on: May 2, 2025

99

Related Concept Videos

The Extrinsic Apoptotic Pathway01:17

The Extrinsic Apoptotic Pathway

The extrinsic apoptotic pathway is initiated when extracellular death-inducing signals, such as specific cytokines, activate the death receptors expressed on the cell surface. The immune cells involved in this pathway are natural killer cells (NK cells) and cytotoxic T-lymphocytes. NK cells are critical in innate immune response, while cytotoxic T-lymphocytes are associated with adaptive immune response. These cells recognize specific receptors expressed on the altered cells and activate...
6.3K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
3.7K
Interactions Between Signaling Pathways01:19

Interactions Between Signaling Pathways

Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
6.2K
Experimental RNAi02:15

Experimental RNAi

RNA interference (RNAi) is a cellular mechanism that inhibits gene expression by suppressing its transcription or activating the RNA degradation process. The mechanism was discovered by Andrew Fire and Craig Mello in 1998 in plants. Today, it is observed in almost all eukaryotes, including protozoa, flies, nematodes, insects, parasites, and mammals. This precise cellular mechanism of gene silencing has been developed into a technique that provides an efficient way to identify and determine the...
6.1K
Regulation of Angiogenesis and Blood Supply01:24

Regulation of Angiogenesis and Blood Supply

Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...
2.5K
Psychoneuroimmunology: Diabetes and Cancer01:19

Psychoneuroimmunology: Diabetes and Cancer

Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
24