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Related Experiment Videos

Hemostatic abnormalities in equine colic.

I B Johnstone, S Crane

    American Journal of Veterinary Research
    |February 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Horses experiencing colic often show blood clotting abnormalities. The severity of these hemostatic issues in horses with gastrointestinal disease varies depending on the specific cause of the colic.

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    Area of Science:

    • Veterinary Medicine
    • Equine Health
    • Hematology

    Background:

    • Colic is a common and serious condition in horses.
    • Gastrointestinal diseases can significantly impact a horse's overall health.
    • Understanding hemostatic function is crucial in managing equine patients.

    Purpose of the Study:

    • To investigate hemostatic profiles in horses presenting with clinical colic.
    • To identify common coagulopathies associated with equine colic.
    • To determine if the cause of colic correlates with the severity of hemostatic abnormalities.

    Main Methods:

    • Collected blood samples from 30 horses with clinical colic upon admission.
    • Performed a comprehensive panel of hemostatic tests, including platelet count, fibrinogen, antithrombin, prothrombin time, partial thromboplastin time, thrombin time, protamine sulfate test, and fibrin-fibrinogen degradation products.

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  • Categorized horses into groups based on the etiology of colic: colitis/diarrhea, torsion/obstruction, and impaction/enteroliths.
  • Main Results:

    • 28 out of 30 horses (93%) exhibited at least one coagulogram abnormality.
    • The most frequent abnormalities included elevated plasma fibrinogen, increased soluble fibrin monomer, prolonged partial thromboplastin time, and prolonged thrombin time.
    • Horses with colitis/diarrhea (Group 1) displayed the most severe coagulopathies, while those with impaction/enteroliths (Group 3) showed fewer abnormalities, primarily elevated fibrinogen and/or soluble fibrin monomer.

    Conclusions:

    • Hemostatic abnormalities are prevalent in horses suffering from gastrointestinal disease and colic.
    • The degree of hemostatic dysfunction appears to be influenced by the underlying cause of the colic.
    • These findings highlight the importance of assessing coagulation status in horses with colic for effective management.