Modulation of epithelial homeostasis by HPV using Notch and Wnt
June See Chong1, John Doorbar1
1Department of Pathology, University of Cambridge, Cambridge, CB2 1QP, UK.
Tumour Virus Research
|November 14, 2024
Summary
Human papillomaviruses (HPVs) disrupt essential Notch and Wnt signaling pathways. This manipulation maintains infected cells in a stem-like state, crucial for HPV persistence and disease development.
Area of Science:
- Cell biology
- Virology
- Molecular biology
Background:
- Notch and Wnt signaling pathways are critical for tissue homeostasis and cell differentiation.
- Human papillomaviruses (HPVs) infect keratinocytes and manipulate host cell pathways.
- HPVs establish a reservoir of infected cells by altering differentiation and proliferation.
Purpose of the Study:
- To investigate the role of Notch and Wnt signaling pathways in HPV infection.
- To understand how HPV E6 and E7 proteins inhibit keratinocyte differentiation.
- To explore the crosstalk between Notch and Wnt pathways in HPV-infected cells.
Main Methods:
- Analysis of conserved signaling pathways (Notch and Wnt).
- Examination of HPV E6 and E7 protein functions.
- Investigation of molecular crosstalk in epithelial homeostasis.
Main Results:
- HPVs manipulate Notch and Wnt pathways to limit keratinocyte differentiation.
- HPV E6 and E7 proteins maintain stem-like characteristics in infected cells.
- Crosstalk between Notch and Wnt pathways is essential for HPV-infected cell reservoir maintenance.
Conclusions:
- Understanding HPV manipulation of Notch and Wnt signaling is vital for comprehending HPV persistence.
- Targeting these pathways may offer therapeutic strategies for HPV-associated diseases.
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