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Polymorphonuclear leukocyte function in cattle with left displaced abomasum with or without concurrent infections.

E O Gyang, R J Markham, E A Usenik

    American Journal of Veterinary Research
    |February 1, 1986
    PubMed
    Summary

    Polymorphonuclear leukocytes (PMN) from cattle with left displaced abomasum (LDA) show reduced phagocytic and bactericidal activities. Concurrent infection further depresses these immune functions in LDA-affected cattle.

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    Area of Science:

    • Veterinary Immunology
    • Ruminant Surgery
    • Bovine Infectious Diseases

    Background:

    • Left displaced abomasum (LDA) is a common gastrointestinal disorder in cattle.
    • Immune function may be compromised in cattle with LDA, potentially increasing susceptibility to infections.
    • Polymorphonuclear leukocytes (PMN) are critical for innate immunity, mediating phagocytosis and bacterial killing.

    Purpose of the Study:

    • To investigate the phagocytic and bactericidal activities of PMN in cattle with LDA.
    • To compare immune cell function between LDA cattle with and without concurrent infections.
    • To assess the effect of surgical correction on PMN function in LDA cattle.

    Main Methods:

    • Blood samples were collected from cattle with LDA (with or without concurrent infection) and healthy controls.

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  • In vitro phagocytic and bactericidal assays were performed on isolated PMN.
  • Levamisole was used in vitro to evaluate its effect on PMN function.

    • Main Results:

    • PMN from cattle with LDA exhibited depressed phagocytic function compared to controls.
    • Cattle with LDA and concurrent infection had lower phagocytic activity and impaired intracellular killing than LDA cattle without infection.
    • PMN function in LDA cattle with infection was altered during surgical correction and recovery.
    • In vitro levamisole treatment enhanced intracellular killing but not phagocytosis in affected cattle.

    Conclusions:

    • LDA in cattle is associated with impaired PMN function, particularly when complicated by infection.
    • Surgical correction and recovery may not fully restore PMN function in infected LDA cattle.
    • Levamisole shows potential for enhancing bactericidal activity in affected animals.