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Starch-based encapsulation to enhance probiotic viability in simulated digestion conditions
Laraib Shoukat1, Sadia Javed1, Muhammad Afzaal2
1Department of Biochemistry, Government College University, Faisalabad, Pakistan.
International Journal of Biological Macromolecules
|November 14, 2024
Summary
Starch-based nanoparticles effectively encapsulate Lactobacillus rhamnosus, enhancing probiotic viability under simulated gastrointestinal conditions. This offers a promising delivery system for food, nutraceutical, and pharmaceutical applications.
Area of Science:
- Materials Science
- Food Science
- Microbiology
Background:
- Efficient delivery systems are crucial for the food, nutraceutical, and pharmaceutical industries.
- Probiotics require protection to maintain viability during processing and digestion.
- Starch-based nanoparticles offer a biodegradable and biocompatible matrix for encapsulation.
Purpose of the Study:
- To synthesize starch-based nanoparticles for encapsulating Lactobacillus rhamnosus.
- To characterize the encapsulated probiotics within microbeads.
- To evaluate the impact of encapsulation on probiotic viability.
Main Methods:
- Synthesis of starch-based nanoparticles.
- Encapsulation of Lactobacillus rhamnosus.
- Characterization using zeta sizer, FTIR, XRD, and SEM.
- Assessment of probiotic viability under simulated gastrointestinal conditions.
Main Results:
- Achieved 85.00% encapsulation efficiency.
- Microscopic analysis confirmed probiotic accumulation within the nanoparticle matrix.
- XRD confirmed amorphous and crystalline properties of the nanoparticles.
- Encapsulation significantly improved probiotic survival under simulated gastrointestinal conditions.
Conclusions:
- Starch-based nanoparticles provide an effective system for probiotic encapsulation.
- Enhanced probiotic viability and stability were demonstrated.
- Potential applications exist across food, nutraceutical, and pharmaceutical industries.
- Further research is needed for long-term stability and functional efficacy studies.
Keywords:
Green approachMicrobeadsProbioticsSimulated gastrointestinal conditionsStarch nanoparticlesViabilityMore Related Videos
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