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Related Concept Videos

Skin Cancer01:30

Skin Cancer

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
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Related Experiment Video

Updated: Jun 7, 2025

An Efficient and Simple Method to Establish NK and T Cell Lines from Patients with Chronic Active Epstein-Barr Virus Infection
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An Efficient and Simple Method to Establish NK and T Cell Lines from Patients with Chronic Active Epstein-Barr Virus Infection

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An Update on EBV-related Cutaneous Lymphoproliferative Disorders: a Systematic Review.

S García-González1, L Prieto-Torres2, M García-García3

  • 1Servicio de Dermatología, Hospital Clínico Universitario Lozano Blesa, Zaragoza, España.

Actas Dermo-Sifiliograficas
|November 14, 2024
PubMed
Summary
This summary is machine-generated.

Epstein Barr virus (EBV) positive lymphoproliferative disorders (LPD) with skin involvement range from indolent to aggressive. This review details B- and T-cell EBV+ LPD characteristics, aiding diagnosis and avoiding overtreatment.

Keywords:
Epstein Barr Virus-Positive B-cell lymphomasEpstein Barr Virus-Positive B-cell lymphoproliferative disordersEpstein Barr Virus-Positive T-cell lymphoproliferative disorderLinfomas B virus de Epstein Barr positivoProceso linfoproliferativo polimorfo B virus de Epstein Barr positivoProcesos linfoproliferativos B virus de Epstein Barr positivoRevisión sistemáticaSystematic review

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Area of Science:

  • Hematology
  • Dermatopathology
  • Oncology

Background:

  • Epstein Barr virus (EBV) positive lymphoproliferative disorders (LPD) with cutaneous involvement encompass a spectrum of rare conditions, from indolent to aggressive lymphomas.
  • While B-cell EBV+ LPD predominantly affect immunocompromised individuals, T-cell EBV+ LPD are more common in specific Asian and South American regions.

Approach:

  • This systematic review synthesizes clinical, histological, immunophenotypic, and molecular data on EBV+ LPD affecting the skin.
  • It covers both primary cutaneous lymphomas and systemic lymphomas with skin manifestations, including EBV-Mucocutaneous Ulcer, lymphomatoid granulomatosis, and various B- and T-cell lymphomas.

Key Points:

  • B-cell EBV+ LPD discussed include EBV-Mucocutaneous Ulcer, lymphomatoid granulomatosis, EBV diffuse large B cell lymphoma, plasmablastic lymphoma, Extracavitary primary effusion lymphoma, EBV-positive polymorphic B cell LPD, and post-transplant lymphoproliferative disorders.
  • T-cell EBV+ LPD categories include T/NK-cell lymphoproliferative processes, childhood lymphomas, extranodal T/NK lymphoma, EBV-positive T-cell centrofollicular lymphoma, and intravascular T/NK-cell lymphoma.
  • Accurate diagnosis relies on integrating clinical, histological, immunohistochemical, and genetic findings.

Conclusions:

  • The classification of hematological malignancies has evolved since the 2018 WHO-EORTC guidelines.
  • Distinguishing between these EBV+ LPD entities presents diagnostic challenges for dermatologists and pathologists.
  • Evidence-based understanding is crucial to prevent overtreatment and ensure appropriate patient management.