Related Experiment Video
Updated: Jun 7, 2025
MicroRNA Based Liquid Biopsy: The Experience of the Plasma miRNA Signature Classifier MSC for Lung Cancer Screening
Published on: October 26, 2017
Malignant pleural effusion risk based on a novel tool using homocysteine and carcinoembryonic antigen in pleural
Jose D Santotoribio1, Juan Corral-Pérez2, David Nuñez-Jurado3
1Department of Laboratory Medicine, Puerto Real University Hospital, Cadiz, Spain; Biomarcadores Group, Instituto De Investigación E Innovación Biomédica De Cádiz (Inibica), Cadiz, Spain; Exphy Research Group, Department Of Physical Education, University Of Cadiz, Cadiz, Spain.
Introduction:
This multicenter study aimed to evaluate the Malignant Pleural Effusion Risk (MPER) diagnostic accuracy in distinguishing between benign and malign pleural effusion.
Methods:
MPER is based on pleural fluid Homocysteine (HCY) and carcinoembryonic antigen (CEA) that were measured using three different methods. MPER was calculated by assessing a previously published probabilistic model: Probability (%) = 100× (1 + e-z)-1, where Z = 0.5471 × [HCY] + 0.3846 × [CEA]-8.2671.
Results:
A total of 301 patients were included (140 MPE). MPER demonstrated a high AUC (0.891), sensitivity (84.3 %), and specificity (80.7 %) with a cut-off > 35.3 %.
Conclusions:
The MPER model demonstrated a high diagnostic accuracy supporting its use as a novel and powerful tool.
More Related Videos
07:47Author Spotlight: Unveiling Transmembrane Protein Family-Related Markers in Gastric Cancer and Implications for Targeted Therapies
Published on: September 15, 2023
07:32Author Spotlight: Investigating Immune Cell Dynamics in the Tumor Microenvironment — Challenges and Innovations in Cancer Prognosis
Published on: April 12, 2024
Related Concept Videos
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
01:25Pleural Effusion I: Introduction
There are two main types of pleural effusion: transudative and exudative. They are differentiated using Light's...