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Optimising detection of thrombosis in paediatric Staphylococcus aureus bacteraemia: A prospective interventional
Keerthi Anpalagan1, Asha C Bowen2, Leanne Lamborn3
1Wesfarmers Centre of Vaccines and Infectious Disease, The Kids Research Institute Australia, Perth, Australia; School of Medicine, University of Western Australia, Perth, Australia.
Infectious Diseases Now
|November 14, 2024
Summary
This study investigates deep venous thrombosis (DVT) in children with Staphylococcus aureus bacteraemia (SAB). The SNOOPY study uses ultrasound to detect DVT, aiming to improve diagnosis and management for pediatric sepsis.
Area of Science:
- Pediatric Infectious Diseases
- Vascular Medicine
- Diagnostic Imaging
Background:
- Staphylococcus aureus bacteraemia (SAB) is a leading cause of pediatric sepsis in Australia and New Zealand.
- Deep venous thrombosis (DVT) is a known complication of invasive S. aureus infections in children, but its frequency and impact on outcomes are unclear.
- Current imaging guidelines for pediatric SAB are not well-defined.
Observation:
- The SNOOPY study is a pilot prospective interventional trial.
- This study will assess the proportion of children with SAB who have venous thrombosis.
- Whole body Doppler ultrasound will be used for thrombosis detection.
Findings:
- This section will report the proportion of pediatric SAB patients with detected venous thrombosis.
- The study aims to establish the frequency of DVT in this population.
- Findings will inform the clinical significance of DVT in pediatric SAB.
Implications:
- This research may lead to improved diagnostic strategies for pediatric SAB.
- Findings could influence clinical management guidelines for children with S. aureus bacteraemia.
- Early detection of DVT may improve patient outcomes and reduce long-term complications.
