Related Experiment Video
Updated: Aug 19, 2026

Assessment of Morphine-induced Hyperalgesia and Analgesic Tolerance in Mice Using Thermal and Mechanical Nociceptive Modalities
Published on: July 29, 2014
Long-term, intermittent percutaneous administration of epidural and intrathecal morphine for pain of malignant origin
Abstract:
Eight patients with intractable pain of malignant origin were treated by the surgical implantation of externalized catheters for percutaneous injection of morphine into the spinal epidural or the cerebral intraventricular space. Follow-up ranged from 48 hr to 1 yr. Four catheters (50%) malfunctioned mechanically and were repaired. Two were imputed in systemic infection and were removed. One patient developed paradoxical responses and discontinued catheter use. Every patient enjoyed excellent relief for a significant time with full preservation of mental capacities. The attractive simplicity of this morphine delivery system deserves further study.
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