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Updated: Jun 7, 2025

A Syngeneic Orthotopic Osteosarcoma Sprague Dawley Rat Model with Amputation to Control Metastasis Rate
Published on: May 3, 2021
CD93 aggravates cell proliferation, angiogenesis and immune escape in osteosarcoma through triggering the PI3K/AKT
Yan Zhang1, Yongheng Liu1, Yulin Ma1
1Department of Bone and Soft Tissue Tumors, Tianjin Medical University Cancer Institute & Hospital, National Clinical Research Center for Cancer, Tianjin's Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060, PR China.
Background:
Osteosarcoma is the most familiar primary malignant tumor occurred in bone in young people and is featured by complicated genetic changes. CD93 has been affirmed to exhibit the facilitative roles in multiple cancers.
Methods:
But, the detailed impacts and related regulatory pathway of CD93 in osteosarcoma progression maintain unclear.
Results:
In this study, the elevated expression of CD93 was verified in osteosarcoma tissues from GEO database. Additionally, it was illustrated that CD93 existed the aggrandized mRNA and protein expressions in osteosarcoma cell lines. Moreover, suppression of CD93 restrained cell proliferation and angiogenesis in osteosarcoma. It was demonstrated that inhibition of CD93 retarded immune escape in osteosarcoma. Furthermore, CD93 triggered the PI3K/AKT pathway to aggravate the progression of osteosarcoma. At last, it was discovered that knockdown of CD93 attenuated tumor growth in vivo.
Conclusions:
In conclusion, this study disclosed that CD93 aggravated cell proliferation, angiogenesis and immune escape in osteosarcoma through triggering the PI3K/AKT pathway. This work may supply useful opinions of CD93 on the cure of osteosarcoma.
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