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Prognostic impact of adipose tissue loss at 1 month after surgery in patients with gastric cancer

  • 0Department of Gastrointestinal Surgery, Kanagawa Cancer Center, Yokohama, Japan.
World Journal of Surgery +

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November 14, 2024

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November 14, 2024

View abstract on PubMed

Summary

This summary is machine-generated.

Short-term adipose tissue loss after gastric cancer surgery is linked to worse survival. This finding highlights the importance of monitoring body composition changes post-operation for better patient outcomes.

Area Of Science

  • Oncology
  • Surgical Oncology
  • Body Composition Analysis

Background

  • The impact of early postoperative skeletal muscle loss (SML) and adipose tissue loss (ATL) on gastric cancer (GC) treatment outcomes remains unclear.
  • This study focuses on the role of SML and ATL at one month post-surgery in predicting survival and recurrence in GC patients.

Purpose Of The Study

  • To investigate the prognostic significance of short-term skeletal muscle and adipose tissue changes after gastric cancer surgery.
  • To determine the association between early postoperative SML and ATL and overall survival (OS) and recurrence-free survival (RFS) in GC patients.

Main Methods

  • Analysis of 540 gastric cancer patients.
  • Assessment of skeletal muscle mass, visceral fat mass, and subcutaneous fat mass using CT scans preoperatively and one month postoperatively.
  • Categorization of patients based on SML, visceral ATL (v-ATL), and subcutaneous ATL (s-ATL) levels, and classification into high, intermediate, and low ATL groups.

Main Results

  • Higher v-ATL and s-ATL were associated with significantly lower OS and RFS rates.
  • High ATL emerged as an independent prognostic factor for reduced OS (HR 2.27) and RFS (HR 2.51).

Conclusions

  • A reduction in adipose tissue volume within one month after surgery may signal an elevated risk of recurrence and mortality in gastric cancer patients.
  • Early postoperative adipose tissue loss is a potential indicator for adverse outcomes in GC survivors.

Keywords: