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Plasma amino acid levels in cataract.
Annals of Ophthalmology
|January 1, 1986
Summary
Fasting plasma amino acid analysis revealed elevated glutamine levels in individuals with cataracts. This study identifies a unique plasma amino acid pattern associated with presenile and senile cataracts.
Area of Science:
- Ophthalmology
- Biochemistry
- Clinical Nutrition
Background:
- Cataracts are a leading cause of vision impairment globally.
- Plasma amino acid profiles are crucial biomarkers for metabolic health.
- Previous research has not extensively explored amino acid alterations in cataractogenesis.
Purpose of the Study:
- To investigate fasting plasma amino acid profiles in individuals with cataracts.
- To compare these profiles with those of individuals with normal lenses.
- To identify potential biochemical markers associated with cataract development.
Main Methods:
- Plasma amino acid levels were measured in 32 subjects (24 with cataracts, 8 with normal lenses).
- Fasting blood samples were analyzed for amino acid composition.
- Results were compared against established age-specific laboratory normal values.
Main Results:
- Individuals with normal lenses exhibited amino acid levels within the expected range.
- Subjects with presenile and senile cataracts showed significantly elevated glutamine levels.
- Elevated alanine was observed in presenile cataracts, and elevated histidine in senile cataracts.
Conclusions:
- A distinct plasma amino acid pattern, characterized by elevated glutamine, is associated with cataracts.
- This finding represents the first reported plasma amino acid profile in individuals with presenile and senile cataracts.
- Further research is warranted to explore the role of these amino acids in cataract formation and progression.