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Related Experiment Video

Updated: May 1, 2026

Construction of a Preclinical Multimodality Phantom Using Tissue-mimicking Materials for Quality Assurance in Tumor Size Measurement
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A call for objectivity: Radiologists' proposed wishlist for response evaluation in solid tumors (RECIST 1.1).

Kathleen Ruchalski1,2, Jordan M Anaokar3, Matthias R Benz3,4

  • 1Department of Radiological Sciences, University of California Los Angeles, Los Angeles, USA. kruchalski@mednet.ucla.edu.

Cancer Imaging : the Official Publication of the International Cancer Imaging Society
|November 15, 2024
PubMed
Summary
This summary is machine-generated.

The Response Evaluation in Solid Tumors (RECIST) 1.1 criteria offer guidance for cancer imaging assessment but rely on subjective measures for non-target and new lesions. Incorporating objective assessments for these could enhance interpretation and clinical relevance.

Keywords:
Biomarkers, TumorClinical trialDisease progressionProgression free survival.RECIST

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Area of Science:

  • Oncology
  • Radiology
  • Clinical Trials

Background:

  • The Response Evaluation in Solid Tumors (RECIST) 1.1 is a standard for imaging response assessment in oncology clinical trials.
  • RECIST 1.1 objectively defines target lesions but relies on qualitative assessments for non-target and new lesions.

Purpose of the Study:

  • To evaluate the impact of RECIST 1.1's subjective assessments on image interpretation and progression-free survival.
  • To explore the potential benefits of incorporating more objective measures for non-target and new lesions within the RECIST framework.

Main Methods:

  • Review of RECIST 1.1 guidelines and literature.
  • Analysis of how subjective assessments of non-target and new lesions affect reader variability.
  • Consideration of previously adopted objective measures by the RECIST Working Group.

Main Results:

  • Subjective assessment of non-target and new lesions introduces reader variability, potentially impacting progression-free survival determination.
  • The RECIST Working Group has explored objective measures for non-target and new lesions.

Conclusions:

  • Prospective evaluation of objective definitions for non-target and new lesions may improve RECIST 1.1 interpretation.
  • Enhanced RECIST criteria could better align with clinically meaningful patient outcomes like survival and quality of life.