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Polymer- and Lipid-Based Nanostructures Serving Wound Healing Applications: A Review.
Fatma N Cetin1, Arn Mignon2, Sandra Van Vlierberghe1
1Department of Organic and Macromolecular Chemistry, Ghent University, Krijgslaan 281, Gent, 9000, Belgium.
Advanced Healthcare Materials
|November 15, 2024
Summary
Supramolecular nanovesicles and nanoparticles offer advanced wound healing capabilities for hard-to-heal wounds. These nanocarriers can introduce hemostatic, anti-inflammatory, and targeted drug delivery functions for next-generation wound care products.
Area of Science:
- Biomaterials Science
- Nanotechnology
- Regenerative Medicine
Background:
- Hard-to-heal wounds require advanced treatments beyond conventional options.
- Current advanced wound care products lack functionality for complex cases like infection, bleeding, and inflammation.
Purpose of the Study:
- To review the potential of supramolecular nanovesicles and nanoparticles in advanced wound healing.
- To explore how these nanocarriers can address unmet needs in managing complex wounds.
Main Methods:
- Literature review of recent reports on supramolecular systems in wound care.
- Analysis of nanocarrier functionalities including hemostasis, drug delivery, and tissue modulation.
Main Results:
- Supramolecular nanovesicles and nanoparticles (dendrimers, micelles, polymersomes, lipid-based nanocarriers) can introduce advanced wound healing properties.
- These systems enable hemostatic functions, transdermal penetration, macrophage polarization, and targeted delivery of active pharmaceutical ingredients.
Conclusions:
- Integration of supramolecular systems is crucial for next-generation wound healing products.
- Nanocarriers offer solutions for personalized therapies and improved transdermal delivery in wound management.
