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[BAEPs of children with malignant tumor undergoing cisplatin treatment]
Insights
Cisplatin chemotherapy can harm the auditory nervous system in children, causing abnormal brainstem auditory evoked potentials (BAEPs). These auditory disturbances may improve after stopping the drug.
Area of Science:
- Pediatric Oncology
- Neuroscience
- Audiology
Context:
- Cisplatin is a widely used chemotherapy agent in pediatric cancers.
- Ototoxicity is a known side effect of cisplatin, but its impact on the auditory nervous system in children requires further investigation.
- Brainstem Auditory Evoked Potentials (BAEPs) are a crucial tool for assessing auditory pathway function.
Purpose:
- To evaluate the effects of cisplatin on the auditory nervous system in pediatric cancer patients.
- To assess changes in auditory function using BAEPs following cisplatin treatment.
- To determine the transient or permanent nature of cisplatin-induced auditory disturbances.
Summary:
- Five children with various cancers (neuroblastoma, yolk sac tumor, neurofibrosarcoma, Hodgkin's disease) received cisplatin (75-105 mg/m2).
- Pre-treatment audiograms were normal in all but one infant.
- Post-treatment BAEPs revealed abnormalities in four patients, including delayed wave I conduction velocity and auditory disturbances in two, which improved upon drug cessation.
Impact:
- Cisplatin frequently impacts the auditory nervous system in children undergoing cancer treatment.
- Auditory nervous system disturbances caused by cisplatin may be transient, particularly in the early stages of treatment.
- Findings highlight the importance of audiological monitoring in pediatric patients receiving cisplatin.
Abstract:
The effect of cisplatin on the auditory nervous system was examined in five children using brainstem auditory evoked potentials (BAEPs). The cases comprized of two neuroblastoma, one yolk sac tumor one neurofibrosarcoma and one Hodgkin's disease. All patients except for one infant aged eight months showed a normal audiogram in the pre-treatment examination. Cisplatin was administered at a dose of 75-105 mg/m2 (body surface area). BAEP tests were performed after cisplatin treatment from two weeks to 20 months. The patients were tested at rest in bed using stimulation with a 3 KHz, 80-dBHL click at 150-msec intervals 2,000 times. Four cases showed an abnormal BAEP pattern in the post-treatment examination. Two of them showed not only delayed conduction velocity of the first wave but also auditory disturbance, but these findings were improved after discontinuation of drug administration. We concluded that cisplatin frequently affects the auditory nervous system, and that this disturbance might be transient in the early stage.