Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Genomic DNA in Eukaryotes00:58

Genomic DNA in Eukaryotes

46.7K
Eukaryotes have large genomes compared to prokaryotes. To fit their genomes into a cell, eukaryotic DNA is packaged extraordinarily tightly inside the nucleus. To achieve this, DNA is tightly wound around proteins called histones, which are packaged into nucleosomes that are joined by linker DNA and coil into chromatin fibers. Additional fibrous proteins further compact the chromatin, which is recognizable as chromosomes during certain phases of cell division.
46.7K
DNA Packaging00:58

DNA Packaging

102.1K
Overview
102.1K
Next-generation Sequencing03:00

Next-generation Sequencing

87.6K
The first human genome sequencing project cost $2.7 billion and was declared complete in 2003, after 15 years of international cooperation and collaboration between several research teams and funding agencies. Today, with the advent of next-generation sequencing technologies, the cost and time of sequencing a human genome have dropped over 100 fold.
Next-Generation Sequencing Methods
Although all next-generation methods use different technologies, they all share a set of standard features....
87.6K
DNA Microarrays02:34

DNA Microarrays

17.2K
Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...
17.2K
DNA as a Genetic Template02:05

DNA as a Genetic Template

21.7K
Two structural features of the DNA molecule provide a basis for the mechanisms of heredity: the four nucleotide bases and its double-stranded nature. The Watson-Crick model of double-helical DNA structure, proposed in 1952, drew heavily upon the X-ray crystallography work of researchers Rosalind Franklin and Maurice Wilkins. Watson, Crick, and Wilkins jointly received the Nobel Prize in Physiology or Medicine for their work in 1962. Franklin was, controversially, excluded from the prize for...
21.7K
From DNA to Protein03:06

From DNA to Protein

18.0K
The flow of genetic information in cells from DNA to mRNA to protein is described by the central dogma, which states that genes specify the sequence of mRNAs, which in turn specify the sequence of amino acids making up all proteins. The decoding of one molecule to another is performed by specific proteins and RNAs. Because the information stored in DNA is so central to cellular function, it makes intuitive sense that the cell would make mRNA copies of this information for protein synthesis...
18.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Self-replication of DNA cross-tile patterns from temperature-selected species.

Nanoscale·2026
Same author

Corrigendum: Gut microbiome alterations during gastric cancer: evidence assessment of case-control studies.

Frontiers in microbiology·2024
Same author

Combined UPLC-QqQ-MS/MS and AP-MALDI Mass Spectrometry Imaging Method for Phospholipidomics in Obese Mouse Kidneys: Alleviation by Feeding Sea Cucumber Phospholipids.

Journal of agricultural and food chemistry·2024
Same author

Effect of cytochrome c release on the mitochondrial-dependent apoptosis and quality deterioration of black rockfish (Sebastes schlegelii) postmortem storage.

Food chemistry·2024
Same author

Identification of metabolites reproducibly associated with Parkinson's Disease via meta-analysis and computational modelling.

NPJ Parkinson's disease·2024
Same author

Dual-channel end-to-end network with prior knowledge embedding for improving spatial resolution of magnetic particle imaging.

Computers in biology and medicine·2024
Same journal

GMSA: A Graph Matching and Point Cloud Registration-Based Method for Spatial Transcriptomics Data Alignment.

Journal of computational biology : a journal of computational molecular cell biology·2026
Same journal

Investigations on Multiple Protein Scaffold Filling.

Journal of computational biology : a journal of computational molecular cell biology·2026
Same journal

Cell Type Prediction for Single-Cell RNA Sequencing Utilizing Unsupervised Domain Adaptation and Semi-Supervised Learning.

Journal of computational biology : a journal of computational molecular cell biology·2026
Same journal

PPIGAN: Prediction of Protein-Protein Interactions Using Generative Adversarial Networks.

Journal of computational biology : a journal of computational molecular cell biology·2026
Same journal

Deep Structure-Enhanced Cell Clustering Model for Single-Cell RNA Sequencing Data.

Journal of computational biology : a journal of computational molecular cell biology·2026
Same journal

Asymmetric Drug-Drug Interaction Prediction Based on Generative Adversarial Networks and Knowledge Graph.

Journal of computational biology : a journal of computational molecular cell biology·2026
See all related articles

Related Experiment Video

Updated: Jun 7, 2025

High-Density DNA and RNA microarrays - Photolithographic Synthesis, Hybridization and Preparation of Large Nucleic Acid Libraries
11:22

High-Density DNA and RNA microarrays - Photolithographic Synthesis, Hybridization and Preparation of Large Nucleic Acid Libraries

Published on: August 12, 2019

18.0K

Adaptive Arithmetic Coding-Based Encoding Method Toward High-Density DNA Storage.

Yingxin Hu1, Yanjun Liu1, Yuefei Yang1

  • 1College of Information Science and Technology, Shijiazhuang Tiedao University, Shijiazhuang, China.

Journal of Computational Biology : a Journal of Computational Molecular Cell Biology
|November 15, 2024
PubMed
Summary
This summary is machine-generated.

A new DNA coding method enhances data storage density and integrity. This approach uses adaptive arithmetic coding (AAC) for compression, octal Hamming code for error correction, and a 3-2 code for biochemical compatibility, improving DNA data storage efficiency.

Keywords:
DNA storageadaptive arithmetic codingcoding constrainthamming error-correcting codesmapping methods

More Related Videos

DNA-Tethered RNA Polymerase for Programmable In vitro Transcription and Molecular Computation
09:26

DNA-Tethered RNA Polymerase for Programmable In vitro Transcription and Molecular Computation

Published on: December 29, 2021

4.1K
Stable DNA Motifs, 1D and 2D Nanostructures Constructed from Small Circular DNA Molecules
09:32

Stable DNA Motifs, 1D and 2D Nanostructures Constructed from Small Circular DNA Molecules

Published on: April 12, 2019

6.4K

Related Experiment Videos

Last Updated: Jun 7, 2025

High-Density DNA and RNA microarrays - Photolithographic Synthesis, Hybridization and Preparation of Large Nucleic Acid Libraries
11:22

High-Density DNA and RNA microarrays - Photolithographic Synthesis, Hybridization and Preparation of Large Nucleic Acid Libraries

Published on: August 12, 2019

18.0K
DNA-Tethered RNA Polymerase for Programmable In vitro Transcription and Molecular Computation
09:26

DNA-Tethered RNA Polymerase for Programmable In vitro Transcription and Molecular Computation

Published on: December 29, 2021

4.1K
Stable DNA Motifs, 1D and 2D Nanostructures Constructed from Small Circular DNA Molecules
09:32

Stable DNA Motifs, 1D and 2D Nanostructures Constructed from Small Circular DNA Molecules

Published on: April 12, 2019

6.4K

Area of Science:

  • Biotechnology
  • Data Storage
  • Bioinformatics

Background:

  • Traditional data storage faces limitations with big data and AI.
  • DNA storage offers superior capacity, density, energy efficiency, and longevity.
  • Efficient DNA coding is crucial for converting digital data into DNA sequences.

Purpose of the Study:

  • To introduce a novel encoding method for DNA data storage.
  • To improve data compression, error correction, and biochemical compatibility in DNA storage.

Main Methods:

  • Developed a three-phase encoding process: compression, error correction, and mapping.
  • Utilized Prediction by Partial Matching (PPM)-based Adaptive Arithmetic Coding (AAC) for compression.
  • Implemented octal Hamming code for error correction and a "3-2 code" for biochemical constraints.

Main Results:

  • Achieved an average coding density of 3.25 bases per nucleotide.
  • Stabilized GC content at 50% and limited homopolymer length to a maximum of 2.
  • Demonstrated effective data integrity preservation and enhanced storage density across various file formats (text, pictures, audio).

Conclusions:

  • The proposed DNA coding method significantly enhances storage density and data integrity.
  • The method exhibits robust error correction capabilities, suitable for diverse data types.
  • This approach addresses key challenges in DNA data storage, paving the way for practical applications.