Towards functional maps of non-coding variants in cancer
Yihan Wang1, Gary C Hon1,2
1Cecil H. and Ida Green Center for Reproductive Biology Sciences, University of Texas Southwestern Medical Center, Dallas, TX, United States.
Frontiers in Genome Editing
|November 15, 2024
Summary
Millions of non-coding variants in cancer genomes are poorly understood. This review covers challenges and new high-throughput technologies for functional annotation to advance personalized cancer therapy.
Area of Science:
- Genomics
- Cancer Biology
- Bioinformatics
Background:
- Large-scale cancer genomic studies have identified millions of non-coding variants.
- The functional roles of most non-coding cancer variants remain unknown.
- Understanding these variants is crucial for advancing cancer research.
Purpose of the Study:
- To review the challenges in functional annotation of non-coding cancer variants.
- To summarize high-throughput technologies for variant analysis.
- To outline future directions in non-coding cancer genetics for personalized therapy.
Main Methods:
- Literature review of functional genomics studies.
- Summary of high-throughput experimental and computational methods.
- Analysis of current challenges and future prospects.
Main Results:
- Significant challenges exist in annotating non-coding variants.
- Emerging high-throughput technologies offer new avenues for functional characterization.
- Non-coding variant analysis holds promise for personalized cancer medicine.
Conclusions:
- Functional annotation of non-coding cancer variants is a critical unmet need.
- Technological advancements are enabling deeper insights into non-coding variant function.
- Harnessing non-coding cancer genetics will be key to future personalized cancer treatments.
Keywords:
cancerenhancers and promotersfunctional genomicsgene regulationgenetic variantsnoncoding regulatory regionsMore Related Videos
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