Suspected agomelatine-induced tongue temperature perception abnormality: a case report

Area of Science:

• Neuroscience
• Pharmacology
• Clinical Medicine

Background:

• Tongue temperature perception abnormality involves altered thermal sensation.
• Altered sensations can occur without actual temperature changes.
• This condition can lead to significant patient discomfort and injury.

Observation:

• A 60-year-old female with depression experienced tongue temperature perception abnormality after one week of agomelatine treatment.
• Symptoms included altered sensation of heat and cold, progressing to burns and blisters.
• Previous treatment with sertraline and oxazepam was ineffective for sleep quality.

Findings:

• The case suggests agomelatine may induce tongue temperature perception abnormality as an adverse drug reaction.
• Discontinuation of agomelatine and initiation of duloxetine led to rapid symptom improvement.
• This indicates a potential causal link between agomelatine and the observed sensory disturbance.

Implications:

• Clinicians should be vigilant for rare adverse drug reactions, including sensory abnormalities, associated with agomelatine.
• Prompt identification and management of drug-induced side effects are crucial for patient safety.
• Further research may be warranted to elucidate the mechanism of agomelatine-induced taste and temperature dysfunctions.