Suspected agomelatine-induced tongue temperature perception abnormality: a case report

Tongue temperature perception abnormality typically refers to an alteration in the tongue's ability to sense temperature, which may manifest as diminished or lost perception of heat or cold, or abnormal sensations in the absence of significant temperature changes. This case report describes a 60-year-old female who developed tongue temperature perception abnormality following the use of agomelatine. The patient had a history of good health, with no surgical or chronic disease history, and no family history of mental illness. She presented with symptoms of emotional depression, irritability, and insomnia, and was diagnosed with depression. Initially treated with sertraline and oxazepam, the treatment was changed to agomelatine due to poor sleep quality. One week after starting agomelatine, the patient reported tongue discomfort, which progressed to temperature perception abnormality, leading to burns and blisters. After discontinuing agomelatine and switching to duloxetine treatment, the symptoms rapidly improved. This case suggests a potential adverse drug reaction induced by agomelatine. The report emphasizes the importance of monitoring drug side effects and timely intervention in clinical practice.