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Published on: July 25, 2017
Serum hsa_circ_0007534 as a diagnostic biomarker for ovarian cancer
Mingyue Cao1,2, Yunchao Gu2, Beidi Lv2
1Department of Gynecology and Oncology, Women's Hospital School of Medicine Zhejiang University No. 1 Bachelor's Road, Shangcheng District, Hangzhou 310006, Zhejiang, China.
Objective:
To investigate the implications of serum hsa_circ_0007534 levels in ovarian cancer (OC) patients.
Methods:
A retrospective analysis was conducted on the clinical data of 102 OC patients, and 102 healthy controls (HCs) were included in this study. Serum levels of hsa_circ_0007534 were measured using qPCR. The relationship between circRNA levels and clinicopathologic characteristics was analyzed. Additionally, the diagnostic performances of serum hsa_circ_0007534 and CA-125 levels in OC patients were evaluated using Receiver Operating Characteristic (ROC) curve analyses.
Results:
OC patients had significantly elevated serum hsa_circ_0007534 levels compared to HCs, allowing a differentiation between OC patients and HCs. Higher serum hsa_circ_0007534 levels were associated with more aggressive disease features and poorer overall survival. Patients with elevated hsa_circ_0007534 levels tended to have worse clinical outcome compared to those with lower levels. Multivariate analyses indicated that high hsa_circ_0007534 levels were independently associated with poorer outcome. Furthermore, serum hsa_circ_0007534 levels effectively distinguished between chemoresistant and chemosensitive patient groups.
Conclusions:
Serum hsa_circ_0007534 levels may serve as valuable predictors of prognosis in OC patients.
