Related Experiment Video
Updated: Jun 7, 2025
Assessment of Vascular Function in Patients With Chronic Kidney Disease
Published on: June 16, 2014
Application value of real-time shear wave elastography for quantitative evaluation of chronic kidney disease in
Jie Zhang1, Linping Liu1, Fang Yang1
1Department of Ultrasound, The Affiliated Children's Hospital of Xiangya School of Medicine, Central South University (Hunan Children's Hospital) Changsha 410007, Hunan, China.
Insights
Real-time shear wave elastography (SWE) effectively quantifies kidney stiffness in pediatric chronic kidney disease (CKD). Higher kidney stiffness (Young's modulus) correlates with fibrosis severity and reduced kidney function, establishing SWE as a valuable non-invasive diagnostic tool.
Area of Science:
- Nephrology
- Medical Imaging
- Pediatric Medicine
Background:
- Chronic kidney disease (CKD) in children poses significant health challenges.
- Accurate, non-invasive methods for assessing CKD severity are crucial for pediatric patients.
- Current diagnostic methods may be invasive or lack quantitative precision.
Purpose of the Study:
- To evaluate the effectiveness of real-time shear wave elastography (SWE) for quantitative assessment of pediatric CKD.
- To determine the correlation between kidney stiffness (Young's modulus, YM) and the degree of interstitial fibrosis (IF) and estimated Glomerular Filtration Rate (eGFR).
Main Methods:
- Shear wave elastography (SWE) was performed on 58 pediatric CKD patients and 70 healthy controls.
- Computer-assisted analysis quantified interstitial fibrosis (IF%) in CKD patients.
- Young's modulus (YM) and eGFR were compared across different fibrosis severity groups and correlated with IF% and eGFR.
Main Results:
- Pediatric CKD patients exhibited significantly higher renal cortex and medulla Young's modulus (YM) compared to healthy controls.
- YM showed significant correlations with interstitial fibrosis (IF%) and estimated Glomerular Filtration Rate (eGFR).
- YM values increased progressively with the severity of renal interstitial fibrosis, with an optimal cut-off of 4.05 kPa for distinguishing CKD.
Conclusions:
- Real-time shear wave elastography (SWE) provides a quantitative, non-invasive method for assessing kidney stiffness in pediatric CKD.
- Kidney YM values are significantly elevated in children with CKD and correlate with disease severity.
- SWE is a promising tool for the quantitative evaluation and management of pediatric chronic kidney disease.
Objective:
To evaluate the effectiveness of real-time shear wave elastography (SWE) in quantitative evaluation of chronic kidney disease (CKD) in pediatric patients.
Methods:
SWE was conducted on 58 pediatric patients with CKD (CKD group) and 70 healthy volunteers (Control group). Computer-assisted quantitative analysis was utilized to determine the percentage of interstitial fibrosis (IF) in images from the CKD group, categorizing them into mild, moderate, and severe groups according to IF% values. The differences in Young's modulus (YM) and estimated Glomerular Filtration Rate (eGFR) between the renal cortex and medulla in these groups were compared. Additionally, the relationships between YM and IF% as well as YM and eGFR, were analyzed.
Results:
The YM values in right lower pole cortex and medulla of the CKD group were significantly higher than those in the control group (all P < 0.05). Significant differences were observed in eGFR among mild, moderate, and severe CKD patients (F = 40.882). YM demonstrated a correlation with eGFR in both the renal cortex and medulla (r = -0.329, P = 0.012; r = 0.417, P = 0.001). YM values increased with the severity of renal interstitial fibrosis in a pronounced trend across groups (F = 109.962, F = 72.950, all P < 0.001). Additionally, YM correlated with IF% in both the renal cortex and medulla (r = 0.362, P = 0.006; r = 0.483, P < 0.001). The optimal cut-off value of renal cortex YM for distinguishing between CKD and control group was 4.05 kPa.
Conclusion:
SWE enables quantitative assessment of kidney YM values, revealing significantly higher values in children with CKD compared to healthy individuals. YM is correlated with the severity of renal interstitial fibrosis, thereby establishing SWE as a valuable non-invasive tool for quantitative evaluation of pediatric CKD.
More Related Videos
06:38Early Detection of Drug-Induced Renal Hemodynamic Dysfunction Using Sonographic Technology in Rats
Published on: March 11, 2016
10:38Observational Study Protocol for Repeated Clinical Examination and Critical Care Ultrasonography Within the Simple Intensive Care Studies
Published on: January 16, 2019
