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Updated: Jun 7, 2025

The MODS method for diagnosis of tuberculosis and multidrug resistant tuberculosis
Published on: August 11, 2008
Updated treatment guidelines for drug-resistant TB: how safe are clofazimine-based regimens?
1Department of Infectious Diseases, Galliera Hospital, Genoa, Italy.
Abstract:
In June 2024, WHO released 'Key updates to the treatment of drug-resistant tuberculosis: rapid communication', after the preliminary publication of results from two clinical trials: 'BEAT-Tuberculosis' and 'endTB'. All proposed regimens include clofazimine (Cfz). However, a recent paper has reported a high incidence of QTc prolongation among patients receiving Cfz-based treatment for multidrug-resistant TB in Taiwan. Here, we discuss the cardiac safety of Cfz and the role of active drug safety monitoring at the programme level in collecting information on this issue.
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