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Updated: Jun 7, 2025
04:23
Application of Hemostatic Devices in Laparoscopic Hepatectomy
Published on: April 19, 2022
2.2K
Hemostats in the clinic.
Maithili Joshi1,2, Zongmin Zhao3, Samir Mitragotri1,2
1John A. Paulson School of Engineering and Applied Sciences Harvard University Allston Massachusetts USA.
Bioengineering & Translational Medicine
|November 15, 2024
Summary
Hemostats, used to control bleeding, have significantly advanced since the 1960s. This review analyzes FDA-approved and investigational hemostats, detailing their ingredients, administration, and applications.
Area of Science:
- Biomedical Engineering
- Pharmacology
- Surgical Innovation
Background:
- Hemostats are critical therapeutics for managing bleeding in hematological conditions, surgery, and trauma.
- Their use improves patient survival rates and quality of life.
- Significant advancements in hemostat technology have occurred since the 1960s.
Purpose of the Study:
- To provide a comprehensive analysis of FDA-approved and investigational hemostats.
- To examine trends in hemostat active ingredients, administration routes, formulations, and indications.
- To identify emerging patterns in hemostats for Hemophilia A and B.
Main Methods:
- Review of FDA-approved hemostats.
- Analysis of hemostats in active clinical trials.
- Comparative assessment of active ingredients, administration, formulation, and disease targets.
Main Results:
- Detailed examination of diverse hemostat formulations and their clinical applications.
- Identification of trends in hemostat development, particularly for specific bleeding disorders.
- Overview of the current landscape and future directions in hemostatic agents.
Conclusions:
- Hemostats represent a dynamic field with continuous innovation in active ingredients and therapeutic applications.
- Understanding current hemostat options and ongoing research is crucial for optimizing bleeding control strategies.
- Future developments promise enhanced efficacy and broader applicability of hemostatic agents.
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