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Improved DeTraC Binary Coyote Net-Based Multiple Instance Learning for Predicting Lymph Node Metastasis of Breast
M Ramkumar1, R Sarath Kumar1, R Padmapriya2
1Electronics and Communication Engineering, Sri Krishna College of Engineering and Technology, Coimbatore, India.
Background:
Early detection of lymph node metastasis in breast cancer is vital for improving treatment outcomes and prognosis.
Methods:
This study introduces an Improved Decompose, Transfer, and Compose Binary Coyote Net-based Multiple Instance Learning (ImDeTraC-BCNet-MIL) method for predicting lymph node metastasis from Whole Slide Images (WSIs) using multiple instance learning. The method involves segmenting WSIs into patches using Otsu and double-dimensional clustering techniques. The developed multiple instance learning approach introduces a paradigm into computational pathology by shaping pathological data and constructing features. ImDeTraC-BCNet-MIL was utilised for feature generation during both training and testing to differentiate lymph node metastasis in WSIs.
Results:
The proposed model achieves the highest accuracy of 95.3% and 99.8%, precision values of 98% and 99.8%, and recall rates of 92.9% and 99.8% on the Camelyon16 and Camelyon17 datasets.
Conclusions:
These findings underscore the effectiveness of ImDeTraC-BCNet-MIL in enhancing the early detection of lymph node metastasis in breast cancer.
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