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Updated: Jun 7, 2025
Stereological and Flow Cytometry Characterization of Leukocyte Subpopulations in Models of Transient or Permanent Cerebral Ischemia
Published on: December 28, 2014
[Image of cerebral leukostasis in a context of acute leukemia]
Annabelle Famerie1, Sophie Gatineau-Sailliant2, Hugues Marechal3
1Service de Pédiatrie générale, CHU Liège, Belgique.
Leukostasis is a classic and well-known complication of acute leukemia when major hyperleukocytosis is present. It affects some organs, notably the central nervous system. The symptoms of cerebral leukostasis are diverse and vary in intensity. Diagnosis of such a condition is iconographic. Treatment relies mainly on two aspects: preventing complications and chemical or mechanical cytoreduction. Currently, the prognosis of patients with cerebral leukostasis is uncertain, although quick resolution of neurological signs is sometimes observed after treatment is initiated.
Leukostasis is a classic and well-known complication of acute leukemia when major hyperleukocytosis is present. It affects some organs, notably the central nervous system. The symptoms of cerebral leukostasis are diverse and vary in intensity. Diagnosis of such a condition is iconographic. Treatment relies mainly on two aspects: preventing complications and chemical or mechanical cytoreduction. Currently, the prognosis of patients with cerebral leukostasis is uncertain, although quick resolution of neurological signs is sometimes observed after treatment is initiated.
