Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Inhibition of Cdk Activity

Inhibition of Cdk Activity

The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...

M-Cdk Drives Transition Into Mitosis

M-Cdk Drives Transition Into Mitosis

Checkpoints throughout the cell cycle serve as safeguards and gatekeepers, allowing the cell cycle to progress in favorable conditions and slow or halt it in problematic ones. This regulation is known as the cell cycle control system.
Cyclin-dependent kinases, or Cdks, work in concert with cyclins to control cell cycle transitions. M-Cdk, a complex of Cdk1 bound to M cyclin, is a well-known example of this coordinated control that drives the transition from the G2 to the M phase.
M cyclin...

Cadherins in Tissue Organization

Cadherins in Tissue Organization

The cadherins are a superfamily of cell adhesion molecules comprising over 180 variants, with specific tissues expressing a particular combination of cadherin types. Cadherins generally exhibit homophilic binding; i.e., cadherins on one cell bind to cadherins of the same or closely related type on another cell. Thus, cells of the same type have a specific affinity to bind to each other and sort themselves into clusters to form tissues.
Cell Sorting During Development
Cell sorting plays an...

Positive Regulator Molecules

Positive Regulator Molecules

Mitotic cell division results in daughter cells that exactly resemble the parent cell. However, errors in the DNA replication or distribution of genetic material may lead to genetic mutations that may be passed down to every new cell formed from the resulting abnormal cell. Propagation of such mutant cells is restricted through checkpoint mechanisms present at different stages of the cell cycle. These checkpoints involve regulator molecules that either promote or demote cell cycle events.

Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...

Structure of Cadherins

Structure of Cadherins

The cadherins were one of the first cell adhesion molecules discovered; the term “cadherins” is based on their calcium-dependent adhering properties. The first cadherins discovered on the epithelial, neuronal, and placental cells were named E-cadherin, P-cadherin, and N-cadherin, respectively. These classical cadherins share sequence and structural similarities. Other cadherins, including those involved in cell signaling, are grouped into non-classical cadherins. This...

Search research articles

Home
Cdh2 And Cdh13 As Potential Prognostic And Therapeutic Targets For Adrenocortical Carcinoma.

Home
Cdh2 And Cdh13 As Potential Prognostic And Therapeutic Targets For Adrenocortical Carcinoma.

Related Experiment Video

Characterization of Cell Membrane Extensions and Studying Their Roles in Cancer Cell Adhesion Dynamics

Characterization of Cell Membrane Extensions and Studying Their Roles in Cancer Cell Adhesion Dynamics

Published on: March 26, 2018

CDH2 and CDH13 as potential prognostic and therapeutic targets for adrenocortical carcinoma.

Yongli Situ¹, Li Deng¹, Ziqing Huang¹

¹Department of Parasitology, Guangdong Medical University, Zhanjiang, China.

Cancer Biology & Therapy

|November 15, 2024

View abstract on PubMed

Summary

This summary is machine-generated.

Cadherin 2 (CDH2) is downregulated and Cadherin 13 (CDH13) is upregulated in adrenocortical carcinoma (ACC), impacting prognosis. These cadherins and their networks offer potential biomarkers and therapeutic targets for ACC.

Keywords:

Bioinformatics cadherin cancer cell cycle gene regulatory network immunotherapy prognosis transcription

More Related Videos

A Novel Method: Super-selective Adrenal Venous Sampling

A Novel Method: Super-selective Adrenal Venous Sampling

Published on: September 15, 2017

Detection of a CDH1 Rare Transcript Variant in Fresh-frozen Gastric Cancer Tissues by Chip-based Digital PCR

Detection of a CDH1 Rare Transcript Variant in Fresh-frozen Gastric Cancer Tissues by Chip-based Digital PCR

Published on: February 5, 2018

Related Experiment Videos

Characterization of Cell Membrane Extensions and Studying Their Roles in Cancer Cell Adhesion Dynamics

Characterization of Cell Membrane Extensions and Studying Their Roles in Cancer Cell Adhesion Dynamics

Published on: March 26, 2018

A Novel Method: Super-selective Adrenal Venous Sampling

A Novel Method: Super-selective Adrenal Venous Sampling

Published on: September 15, 2017

Detection of a CDH1 Rare Transcript Variant in Fresh-frozen Gastric Cancer Tissues by Chip-based Digital PCR

Detection of a CDH1 Rare Transcript Variant in Fresh-frozen Gastric Cancer Tissues by Chip-based Digital PCR

Published on: February 5, 2018

Area of Science:

Oncology
Molecular Biology
Bioinformatics

Background:

Cadherin 2 (CDH2) and Cadherin 13 (CDH13) are implicated in various cancers.
Their specific roles and regulatory mechanisms in adrenocortical carcinoma (ACC) are not well-defined.

Purpose of the Study:

To investigate the expression patterns, prognostic significance, and regulatory networks of CDH2 and CDH13 in ACC.
To identify potential therapeutic targets and biomarkers for ACC.

Main Methods:

Bioinformatic analyses of gene expression, regulatory networks, and prognostic values.
Analysis of CDH2 and CDH13 expression in 75 ACC patients.
Identification of miRNA and kinase targets.

Main Results:

CDH2 was significantly downregulated, while CDH13 was significantly upregulated in ACC.
Altered expression of CDH2 and CDH13, and their neighboring genes, impacts tumor-related gene expression, cell cycle, metabolism, and integrin function.
CDH13 expression correlated positively with immune cell infiltration and was downregulated by immunotherapy.
Foretinib and elesclomol showed potential to inhibit ACC cells by targeting CDH2 and CDH13.

Conclusions:

CDH2 and CDH13 play crucial roles in ACC development and progression.
These cadherins represent promising biomarkers for ACC prognosis and potential targets for precision therapy.