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Accelerometer-Measured Sedentary Behavior and Risk of Future Cardiovascular Disease
Ezimamaka Ajufo1, Shinwan Kany2, Joel T Rämö3
1Cardiology Division, Brigham and Women's Hospital, Boston, Massachusetts, USA; Cardiovascular Disease Initiative, The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
Journal of the American College of Cardiology
|November 15, 2024
Summary
High sedentary time is linked to increased cardiovascular disease risk, especially heart failure and mortality. Reducing sedentary behavior is crucial for heart health, even for those meeting physical activity guidelines.
Area of Science:
- Cardiology
- Public Health
- Epidemiology
Background:
- Sedentary behavior is a marker of insufficient physical activity.
- Sedentary behavior may independently increase cardiovascular disease risk.
Purpose of the Study:
- Examine associations between sedentary behavior and cardiovascular outcomes.
- Investigate the relationship between sedentary time and moderate to vigorous physical activity (MVPA).
Main Methods:
- Utilized UK Biobank prospective cohort data.
- Employed Cox models to assess sedentary time and cardiovascular disease risk.
- Conducted compositional analyses to evaluate activity reallocation.
Main Results:
- Increased sedentary time (>10.6 h/d) correlated with higher risks of heart failure and cardiovascular mortality.
- Sedentary time showed linear associations with atrial fibrillation and myocardial infarction.
- Reducing sedentary time mitigated excess cardiovascular risk, irrespective of MVPA levels.
Conclusions:
- Sedentary behavior is broadly linked to adverse cardiovascular outcomes.
- Heart failure and cardiovascular mortality risks significantly increase with sedentary time.
- Optimizing sedentary behavior is vital for cardiovascular health, even in physically active individuals.
