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Intraoperative Assessment of Resection Margins in Oral Cavity Cancer: This is the Way

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Modified Textbook Outcome was a Predictor for Early Mortality After Oral Cancer Surgery.

Ling-Jan Chiou¹, Ching-Chih Lee^2,3,4,5,6

¹Department of Healthcare Administration, Asia University, Taichung, Taiwan, R.O.C.

Annals of Surgical Oncology

|November 15, 2024

Summary

Early death in oral cavity cancer (OCC) patients is predicted by non-modified textbook outcome (mTO) and cancer resource center (CRC) visits, alongside traditional factors. A new nomogram aids survival prediction for improved patient outcomes.

Keywords:

Early death Oral cancer Survival

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Area of Science:

Oncology
Surgical Oncology
Cancer Prognostics

Background:

Oral cavity cancer (OCC) presents significant challenges for patient survival.
Early mortality following surgery for OCC requires identification of key prognostic factors.

Purpose of the Study:

To identify prognostic factors for early mortality in oral cavity cancer (OCC) patients.
To develop strategies for improving patient outcomes after OCC surgery.

Main Methods:

Retrospective analysis of 397 patients undergoing primary tumor resection and neck dissection (2017-2021).
Univariate and multivariate Cox regression analysis to determine predictors of early death (within 12 months).
Development of a nomogram to estimate 1-year overall survival (OS).

Main Results:

The overall early death rate was 12.6%.
Independent prognosticators for early mortality included non-modified textbook outcome (mTO), advanced nodal stage (pN2-3), larger tumor size (>3 cm), and lymphovascular invasion.
A nomogram incorporating these factors demonstrated good predictive performance.

Conclusions:

Non-mTO and cancer resource center (CRC) visits are significant prognostic factors for early death in OCC, in addition to clinicopathological features.
A validated nomogram can aid in predicting survival.
Improving mTO and patient access to resources may enhance survival outcomes in OCC.