A prospective split-mouth clinical study: comparison of the effect of lornoxicam and etodolac on postoperative...

Area of Science:

• Oral and Maxillofacial Surgery
• Pharmacology
• Pain Management

Background:

• Impacted lower third molars frequently require surgical extraction.
• Postoperative pain, edema, and trismus are common complications following this procedure.
• Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly used for managing these symptoms.

Purpose of the Study:

• To compare the efficacy of lornoxicam and etodolac in managing postoperative pain, edema, and trismus.
• To evaluate these NSAIDs after the surgical removal of impacted lower third molars.

Main Methods:

• A randomized study involving 20 patients with bilateral impacted lower third molars.
• Patients received either 8 mg lornoxicam or 400 mg etodolac post-extraction.
• Pain (Visual Analog Scale), edema (reference lines), and trismus (mouth opening measurement) were assessed.

Main Results:

• No statistically significant differences were observed in postoperative pain between the lornoxicam and etodolac groups (p > 0.05).
• Similarly, no significant differences in edema or trismus were found between the two treatment groups.
• Both NSAIDs demonstrated comparable outcomes in managing the assessed postoperative sequelae.

Conclusions:

• Lornoxicam and etodolac are equally effective in managing pain, edema, and trismus after impacted lower third molar surgery.
• Both agents provide adequate pain control and similar impacts on swelling and jaw mobility.
• Clinicians can consider either lornoxicam or etodolac for postoperative care following third molar extractions.