Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Ethanol blockade of context change effects.

L D Devenport, N Cater

    Behavioral and Neural Biology
    |January 1, 1986
    PubMed
    Summary

    Alcohol pretreatment prevented spatial memory disruption in rats when the testing environment changed. This suggests alcohol may alter how animals form or react to environmental memories.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Bimonthly update: lipidology. Therapy and clinical trials.

    Current opinion in lipidology·1998
    Same author

    Relative contribution of type I and II corticosterone receptors in VMH lesion-induced obesity and hyperinsulinemia.

    The American journal of physiology·1994
    Same author

    Time-dependent decisions in dogs (Canis familiaris).

    Journal of comparative psychology (Washington, D.C. : 1983)·1993
    Same author

    Contributions of hippocampus and neocortex to the expression of ethanol effects.

    Psychopharmacology·1989
    Same author

    Site specificity of adrenalectomy-induced brain growth.

    Experimental neurology·1988
    Same author

    Sampling behavior in the radial maze and operant chamber: role of the hippocampus and prefrontal area.

    Behavioral neuroscience·1988

    Area of Science:

    • Neuroscience
    • Behavioral Neuroscience
    • Cognitive Psychology

    Background:

    • Spatial learning and memory are crucial for navigation.
    • Environmental context plays a significant role in memory recall.
    • Alcohol's effects on cognitive functions, including memory and context-dependent learning, require further elucidation.

    Purpose of the Study:

    • To investigate the impact of alcohol pretreatment on context-dependent spatial memory in rats.
    • To determine if alcohol affects the disruption caused by a change in training and testing environments.

    Main Methods:

    • Rats were trained on an eight-arm radial maze in distinct contexts.
    • Subjects received either alcohol (1.5 g/kg ethanol) or saline pretreatment.
    • Context conditions were reversed for testing while drug treatment remained consistent.

    Main Results:

    • Saline-treated rats showed significant disruption in performance after the context shift.
    • Alcohol-treated rats were not affected by the change in environmental context.
    • This indicates alcohol mitigated the negative impact of the context change on spatial memory.

    Conclusions:

    • Alcohol may impair the formation of context-specific memories.
    • Alternatively, alcohol might block the behavioral response to environmental mismatch.
    • Findings suggest a role for alcohol in modulating the influence of environmental cues on memory retrieval.

    Related Experiment Videos