Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Obesity01:24

Obesity

381
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
381
Regulation of Food Intake01:30

Regulation of Food Intake

193
Short-term regulation of food intake primarily involves neural signals from the gastrointestinal (GI) tract, blood nutrient levels, and GI tract hormones. Communication between the gut and brain via vagal nerve fibers plays a significant role in evaluating the contents of the gut. Clinical studies have shown that protein ingestion produces a more prolonged response in these nerve fibers compared to an equivalent amount of glucose. Additionally, the activation of stretch receptors caused by GI...
193
Hypothalamic-Pituitary Axis01:37

Hypothalamic-Pituitary Axis

59.3K
The response to stress—be it physical or psychological, acute or chronic—involves activation of the Hypothalamic-Pituitary-Adrenal (HPA) axis. The HPA axis is part of the neuroendocrine system because it involves both neuronal and hormonal communication. Its function is to regulate homeostatic systems—metabolic, cardiovascular, and immune—providing the necessary means to respond to a stressor.
59.3K
Primary Motives: Hunger and Thirst01:25

Primary Motives: Hunger and Thirst

160
Hunger and thirst are fundamental physiological drives crucial for maintaining homeostasis and ensuring the survival of both humans and animals. These drives are regulated through complex interactions between the brain, hormones, and sensory receptors.
Hunger arises when the brain detects changes in the body's nutrient levels, including glucose, lipids, amino acids, and hormones such as ghrelin and leptin. The hypothalamus plays a central role in hunger regulation. The lateral hypothalamus...
160
Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

872
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
872
Bulimia Nervosa01:30

Bulimia Nervosa

52
Bulimia nervosa is a complex and severe eating disorder characterized by a cyclical pattern of binge-and-purge eating pattern. It generally involves an episode of binge eating, followed by compensatory behaviors such as vomiting, excessive exercise, laxative use, or fasting, to prevent weight gain. Despite often maintaining a normal weight, individuals with bulimia are intensely preoccupied with their body image and harbor an overwhelming fear of gaining weight. This can contribute to the...
52

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Treating Acquired Hypothalamic Obesity.

The New England journal of medicine·2026
Same author

Whole-population trends in obesity across dimensions of inequality in England, 2019-25: a retrospective, longitudinal cohort study of 54 million adults.

The lancet. Diabetes & endocrinology·2026
Same author

Visual morbidity, long-term outcome and prognostic factors in infants and young children with optic pathway low-grade glioma.

Neuro-oncology practice·2026
Same author

Autophagy and primary cilium: A dynamic duo in cellular homeostasis and disease.

International review of cell and molecular biology·2026
Same author

A Hormone Cell Atlas maps the human endocrine system at cellular resolution.

Science (New York, N.Y.)·2026
Same author

Autophagy: Bridging the brain-periphery connection.

Neural regeneration research·2026

Related Experiment Video

Updated: Jun 7, 2025

Control of Eating Behavior Using a Novel Feedback System
04:48

Control of Eating Behavior Using a Novel Feedback System

Published on: May 8, 2018

10.9K

Hypothalamic obesity: from basic mechanisms to clinical perspectives.

Jesús Argente1, I Sadaf Farooqi2, Julie A Chowen3

  • 1Department of Endocrinology, Hospital Infantil Universitario Niño Jesús, Instituto de Investigación La Princesa, Madrid, Spain; IMDEA-Food Institute, Madrid, Spain; Department of Pediatrics, Universidad Autónoma de Madrid, Madrid, Spain; CIBER Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, Madrid, Spain.

The Lancet. Diabetes & Endocrinology
|November 15, 2024
PubMed
Summary
This summary is machine-generated.

Brain circuits, particularly the hypothalamus, play a key role in obesity. Hypothalamic obesity, a rare severe form, stems from specific brain circuit disruptions, requiring targeted diagnosis and treatment.

More Related Videos

Mechanism of Regulation of Adipocyte Numbers in Adult Organisms Through Differentiation and Apoptosis Homeostasis
08:34

Mechanism of Regulation of Adipocyte Numbers in Adult Organisms Through Differentiation and Apoptosis Homeostasis

Published on: June 3, 2016

15.0K
Author Spotlight: Hypothalamic Neural Mechanism Insights
09:29

Author Spotlight: Hypothalamic Neural Mechanism Insights

Published on: August 4, 2023

3.4K

Related Experiment Videos

Last Updated: Jun 7, 2025

Control of Eating Behavior Using a Novel Feedback System
04:48

Control of Eating Behavior Using a Novel Feedback System

Published on: May 8, 2018

10.9K
Mechanism of Regulation of Adipocyte Numbers in Adult Organisms Through Differentiation and Apoptosis Homeostasis
08:34

Mechanism of Regulation of Adipocyte Numbers in Adult Organisms Through Differentiation and Apoptosis Homeostasis

Published on: June 3, 2016

15.0K
Author Spotlight: Hypothalamic Neural Mechanism Insights
09:29

Author Spotlight: Hypothalamic Neural Mechanism Insights

Published on: August 4, 2023

3.4K

Area of Science:

  • Neuroscience
  • Endocrinology
  • Genetics

Background:

  • Obesity has diverse causes, but compelling evidence highlights the significant contribution of brain circuits.
  • The hypothalamus is central to bodyweight homeostasis; its deregulation can cause obesity.
  • Hypothalamic obesity refers to rare, severe obesity linked to identifiable genetic or acquired hypothalamic dysfunction.

Purpose of the Study:

  • To provide a comprehensive overview of hypothalamic obesity, covering pathogenesis, clinical presentation, and therapeutic targets.
  • To elucidate the physiological basis of hypothalamic pathways in bodyweight control.
  • To explore mechanisms of hypothalamic pathway perturbation and their consequences.

Main Methods:

  • Review of existing genetic, clinical, and experimental evidence.
  • Analysis of physiological mechanisms governing hypothalamic bodyweight control.
  • Examination of genetic and acquired causes of hypothalamic pathway dysfunction.

Main Results:

  • The hypothalamus is a critical regulator of bodyweight homeostasis.
  • Perturbations in hypothalamic pathways, whether genetic or acquired, are implicated in obesity.
  • Understanding these pathways is crucial for diagnosing and treating hypothalamic obesity.

Conclusions:

  • Hypothalamic obesity is a distinct entity requiring specialized understanding.
  • Current developments offer new avenues for precise diagnosis and treatment.
  • Further research into hypothalamic mechanisms is essential for effective therapeutic strategies.