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Related Experiment Video

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Neohesperidin protects against colitis-associated colorectal cancer in mice via suppression of the NF-κB/p65 and MAPK

Xingyue Cao1, Lingling Li1, Jianing Hu1

  • 1Key Laboratory of Human Genetics and Environmental Medicine, School of Public Health, Xuzhou Medical University, Xuzhou, 221004, China.

The Journal of Nutritional Biochemistry
|November 15, 2024
PubMed
Summary
This summary is machine-generated.

Neohesperidin (NHP) effectively reduced colitis and colon cancer in a mouse model. This citrus flavanone inhibited tumor growth, promoted apoptosis, and reduced inflammation, showing promise for inflammatory bowel disease (IBD) and colitis-associated colorectal cancer (CAC) treatment.

Keywords:
Colitis-associated colorectal cancerInflammationMAPKNF-κBNeohesperidin

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Area of Science:

  • Biochemistry
  • Pharmacology
  • Oncology

Background:

  • Inflammatory bowel disease (IBD) patients face elevated risks for colitis-associated colorectal cancer (CAC).
  • Neohesperidin (NHP), a citrus flavanone, exhibits known anti-inflammatory, antioxidant, and anticancer properties.
  • The specific role of NHP in preventing colon tumorigenesis remains largely uncharacterized.

Purpose of the Study:

  • To investigate the chemopreventive potential of Neohesperidin (NHP) against colitis-associated colorectal cancer (CAC) development.
  • To evaluate the efficacy of NHP in an established in vivo model of CAC.

Main Methods:

  • An azoxymethane (AOM)/dextran sulfate sodium (DSS) mouse model was employed to induce colitis and CAC.
  • NHP was administered daily via oral gavage for 10 weeks throughout the experimental period.
  • Key markers of inflammation, proliferation, apoptosis, angiogenesis, and relevant signaling pathways (NF-κB, MAPK) were assessed.

Main Results:

  • NHP significantly ameliorated colitis symptoms and suppressed colon tumor formation in the AOM/DSS model.
  • NHP treatment attenuated tumor cell proliferation, induced apoptosis, and inhibited angiogenesis.
  • NHP reduced macrophage infiltration and suppressed pro-inflammatory cytokines (TNF-α, IL-1β, IL-6, COX-2) in a dose-dependent manner.
  • NHP demonstrated superior or comparable efficacy to mesalazine, a standard therapeutic agent.

Conclusions:

  • Neohesperidin (NHP) possesses significant chemopreventive effects against colitis-associated colorectal cancer (CAC).
  • NHP exerts its effects by reducing inflammation, inhibiting tumor growth, and modulating key cellular pathways.
  • NHP represents a promising therapeutic candidate for managing IBD and preventing CAC.