Psychotropic-induced weight gain and telomere length: results from a one-year longitudinal study and a large population-based cohort
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View abstract on PubMed
Summary
This summary is machine-generated.Weight-inducing psychotropic medications accelerate telomere shortening, especially in patients with low baseline weight and significant weight gain. This process is linked to increased inflammation and body mass index (BMI).
Area Of Science
- Genetics and Aging Research
- Psychopharmacology and Metabolic Health
Background
- Weight gain from psychotropic medications is a risk factor for age-related diseases, including cardiovascular disorders.
- Cardiovascular disorders are linked to inflammation and telomere length shortening, key indicators of cellular aging.
Purpose Of The Study
- To evaluate telomere length trajectories after one year of weight-inducing psychotropic medication.
- To assess the influence of weight changes and high-sensitivity C-Reactive Protein (CRP) on telomere length.
Main Methods
- Longitudinal study of 200 patients treated with weight-inducing psychotropic medications.
- Analysis of telomere length, body mass index (BMI), and CRP levels over one year.
- Mendelian randomization using UKBiobank data to establish causal relationships.
Main Results
- A median telomere shortening of -41.2 bp was observed, comparable to the general population.
- Increased BMI significantly accelerated telomere shortening, particularly in patients with lower baseline weight and substantial weight gain (≥7%).
- Weight gain correlated with higher CRP levels, and elevated CRP levels were associated with accelerated telomere shortening.
Conclusions
- Telomere shortening is associated with weight gain and increased CRP levels after one year of psychotropic treatment.
- BMI increments significantly enhance telomere shortening in patients on weight-inducing psychotropic medications.
- Findings highlight the accelerated aging impact of certain psychotropic treatments, mediated by weight gain and inflammation.
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