Expression of TSPAN1 and its link to thyroid nodules: one step forward on the path to thyroid tumorigenesis biomarkers
Contact us if these videos are not relevant.
Contact us if these videos are not relevant.
View abstract on PubMed
Summary
This summary is machine-generated.TSPAN1 protein and mRNA levels are significantly reduced in thyroid cancer patients. This decrease suggests TSPAN1 may serve as a potential biomarker for diagnosing thyroid malignancies.
Area Of Science
- Endocrinology
- Oncology
- Molecular Biology
Background
- Thyroid cancer is a common endocrine malignancy, ranking seventh globally in women.
- Accurate diagnosis of thyroid malignancies requires reliable biomarkers.
- TSPAN1 was investigated as a potential biomarker in plasma and tissue samples.
Purpose Of The Study
- To evaluate TSPAN1 mRNA and protein levels in individuals with thyroid nodules.
- To determine if TSPAN1 can differentiate between papillary thyroid cancer (PTC), benign nodules, and healthy individuals.
Main Methods
- A case-control study involving 90 subjects: 60 with PTC, 30 with benign nodules, and 26 healthy controls.
- TSPAN1 protein levels were measured using enzyme-linked immunosorbent assay (ELISA).
- TSPAN1 mRNA levels were quantified using SYBR-Green Real-Time PCR.
Main Results
- TSPAN1 plasma levels were significantly lower in both PTC and benign groups compared to healthy subjects (P=0.002).
- TSPAN1 mRNA levels were decreased in PTC tumor tissues compared to normal tissues (P=0.012) and in PTC patients versus benign patients (P=0.001).
- TSPAN1 demonstrated diagnostic value for PTC detection with 76.7% sensitivity and 65.4% specificity at a cutoff <2.7 ng/ml.
Conclusions
- Reduced TSPAN1 levels in benign and PTC patients indicate its potential as a diagnostic biomarker.
- Decreased TSPAN1 mRNA expression in PTC tissues suggests a role in tumor progression.
- Further research is needed to elucidate TSPAN1's molecular mechanisms and clinical utility in thyroid disorders.
Contact us if these videos are not relevant.
Contact us if these videos are not relevant.
Related Concept Videos
Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
The TGF-β signaling pathway regulates cell growth, differentiation, adhesion, motility, and development. TGF-β ligands that induce TGF-β signaling are synthesized in their latent form. Several proteases or cell surface receptors such as integrins act upon the latent form, releasing the active ligand. There are three types of mammalian TGF-βs: (TGF-β1, TGF-β2, and TGF-β3) that bind as homodimers or heterodimers to TGF-β receptors. The TGF-β receptors...
As the name suggests, non-LTR retrotransposons lack the long terminal repeats characteristic of the LTR retrotransposons. Additionally, both LTR and non-LTR retrotransposons use distinct mechanisms of mobilization. Non-LTR retrotransposons are further divided into two classes - Long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs), both of which occur abundantly in most mammals, including humans. Some of the active non-LTR retrotransposons in humans are L1...
The nucleolus is the most prominent substructure of the nucleus. When it was first discovered, it was considered to be an isolated organelle that forms fibrils and granules. In 1931, the relationship between the nucleolus and chromosomes was first described by Heitz. He observed that the appearance and size of nucleolus varies depending on the stage of the cell cycle. He also noticed constricted regions on different chromosomes clustered together at definite cell cycle stages. These regions,...