Related Experiment Video
Updated: Jul 16, 2026
09:35
Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect
Published on: September 11, 2015
9.7K
Plant-based scaffolds and osteogenesis: A systematic review
Hashmat Gul1, Kunza Naveed Asdaq1, Muhammad Kaleem1
1Department of Science of Dental Materials, Army Medical College, National University of Medical Sciences, Rawalpindi, Pakistan.
JPMA. the Journal of the Pakistan Medical Association
|November 16, 2024
Summary
Plant-based scaffolds show promise for bone regeneration and osteogenesis. However, further in vivo research is essential to establish their suitability for bone tissue engineering applications.
Area of Science:
- Biomaterials Science
- Tissue Engineering
- Regenerative Medicine
Background:
- Decellularised plant tissues offer a sustainable and biocompatible source for scaffold development.
- Plant-based materials present a promising alternative to traditional synthetic or animal-derived scaffolds in bone tissue engineering.
Purpose of the Study:
- To review recent advances in plant-based scaffolds for bone regeneration.
- To enhance the understanding of decellularised plant tissues as scaffolds for bone tissue engineering.
Main Methods:
- A systematic literature review was conducted from February to June 2022.
- Searches included PubMed, Science Direct, and Google Scholar using keywords related to plant-based scaffolds and osteogenesis.
- Ten full-text articles published between 2013 and 2022, focusing on in vitro and in vivo studies, were included after quality evaluation.
Main Results:
- Six studies (60%) were in vitro, and four (40%) included both in vitro and in vivo components.
- Decellularised plant tissue was used as a 3D scaffold in 50% of studies; composite scaffolds were used in 40%.
- The majority of studies (70%) presented a medium risk of bias.
Conclusions:
- Plant-based scaffolds demonstrate potential in promoting osteogenesis.
- Additional in vivo investigations are required to validate plant-based scaffolds for bone tissue engineering.
- Further research should focus on optimizing plant-based scaffold design and evaluating their long-term efficacy in bone regeneration.
Related Concept Videos
01:02What is the Skeletal System?
Overview
01:55Bone Structure
Within the skeletal system, the structure of a bone, or osseous tissue, can be exemplified in a long bone, like the femur, where there are two types of osseous tissue: cortical and cancellous.
01:23Bone as Supporting Connective Tissue
Bone tissue forms the internal skeleton of vertebrate animals, providing structure to the body.
Bone Matrix
Bone, or osseous tissue, is a connective tissue that has a large amount of two different types of matrix material. The organic matrix is similar to the matrix material found in other connective tissues, including some amount of collagen and elastic fibers. This gives strength and flexibility to the tissue. The inorganic matrix consists of mineral salts— mostly calcium salts— that give the...
Bone Matrix
Bone, or osseous tissue, is a connective tissue that has a large amount of two different types of matrix material. The organic matrix is similar to the matrix material found in other connective tissues, including some amount of collagen and elastic fibers. This gives strength and flexibility to the tissue. The inorganic matrix consists of mineral salts— mostly calcium salts— that give the...
01:27Fractures: Bone Repair
Treatment for a fracture is based on the type of break, the bone affected, and the patient's age.
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the procedure...
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the procedure...
01:31Bone Remodeling and Repair
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
01:20Introduction to the Skeletal System
The skeletal system is the central framework of the body, consisting of different connective tissues: bones, cartilage, tendons, and ligaments.
Components of the Skeletal System
Bone, or osseous tissue, is a hard connective tissue that forms an internal support structure for the human body. Bones shield vulnerable organs and soft tissue from external forces. For example, the vertebral bones protect and support the spinal cord.
Cartilage, a semi-rigid connective tissue found in regions such as...
Components of the Skeletal System
Bone, or osseous tissue, is a hard connective tissue that forms an internal support structure for the human body. Bones shield vulnerable organs and soft tissue from external forces. For example, the vertebral bones protect and support the spinal cord.
Cartilage, a semi-rigid connective tissue found in regions such as...