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Physio-Friendly Remission-Facilitating Pharmacotherapy (PRP) in Type 2 Diabetes
Sanjay Kalra1, Suneet Verma2, Nitin Kapoor3
1Department of Endocrinology, Bharti Hospital, Karnal, India; University Center for Research & Development, Chandigarh University, Mohali, India.
JPMA. the Journal of the Pakistan Medical Association
|November 16, 2024
Summary
Physio-friendly pharmacotherapy for type 2 diabetes aims to restore metabolic balance. Certain medications, like GLP1 receptor agonists and SGLT2 inhibitors, facilitate remission by mimicking natural physiological processes.
Area of Science:
- Endocrinology
- Metabolic Diseases
- Pharmacology
Background:
- Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by hyperglycemia.
- Effective management of T2DM requires restoring metabolic homeostasis, including glycemic control and weight management.
- Current therapeutic approaches often focus on symptom management rather than physiological restoration.
Purpose of the Study:
- To introduce and define the concept of physio-friendly pharmacotherapy for T2DM.
- To identify drug classes that align with the principles of physio-friendly therapy.
- To highlight the potential of these therapies in facilitating diabetes remission.
Main Methods:
- Conceptual analysis of existing pharmacotherapy for T2DM.
- Identification of drugs that restore metabolic homeostasis (glycemic and weight).
- Classification of drugs based on their ability to facilitate remission.
Main Results:
- Physio-friendly therapy restores metabolic, glycemic, and weight homeostasis to near-normal levels.
- Glucagon-like peptide 1 receptor agonists (GLP1RA), sodium-glucose cotransporter-2 inhibitors (SGLT2i), alpha-glucosidase inhibitors, and metformin exhibit physio-friendly properties.
- These agents can be termed remission-facilitating drugs due to their ability to promote diabetes remission.
Conclusions:
- Physio-friendly pharmacotherapy represents a paradigm shift in T2DM management, focusing on restoring physiological balance.
- GLP1RA, SGLT2i, alpha-glucosidase inhibitors, and metformin are key drug classes that support this approach.
- These therapies hold significant promise for achieving and sustaining remission in type 2 diabetes.
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